| ARTICLES |
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| Year : 1997 | Volume
: 3
| Issue : 3 | Page : 113-120 |
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Acute pancreatitis
Ibrahim Abdulkarim Al Mofleh
Department of Medicine, College of Medicine, KSU, Riyadh, Saudi Arabia
Correspondence Address:
Ibrahim Abdulkarim Al Mofleh
Professor of Medicine, Gastroenterology Division (59), King Khalid University Hospital, P.O. Box 2925, Riyadh 11461
Saudi Arabia
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 19864787 
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The past few years have witnessed a tremendous progress in our knowledge regarding the pathogenesis, diagnosis, prognostic evaluation and classification of acute pancreatitis. The role of ischemia, lysosomal enzymes, oxygen free radicals, polymorphnuclear cells-byproducts and inflammatory mediators in the pathogenesis of pancreatic necrosis and multiple organ failure has been emphasized. Furthermore, the recent knowledge about agents infecting pancreatic necrosis, routes of infection, bacteriological examination of fine needle aspirate and appropriate antibiotics have changed the concept of acute pancreatitis. New diagnostic tests such as rapid urinary trypsinogen-2 test and inflammatory mediators including polymorphnuclear elastase, C-reactive protein and interleukin-6 contribute to early diagnosis, prognostic evaluation and initiation of an appropriate therapy. |
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