Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2006  |  Volume : 12  |  Issue : 2  |  Page : 73-76

Clinical presentation, response to therapy, and predictors of fibrosis in patients with autoimmune hepatitis in Saudi Arabia


Division of Gastroenterology College of Medicine, King Saud University, Saudi Arabia

Correspondence Address:
Ayman A Abdo
P.O. Bob 2925(59) Riyadh 11461
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.27849

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Background: Autoimmune hepatitis (AIH) is a relapsing inflammatory disease of the liver of unknown cause. Little is known about AIH in Saudi Arabia. Objectives: Our aim is to [1] identify the special clinical or histological features in our patients[2], describe the initial response to immunosuppressive therapy and long term relapse[3], identify clinical and laboratory predictors of response to therapy, and [4] examine the utility of laboratory markers (platelet count, AST/ALT ratio, and the AST to platelet ratio index (APRI score) in predicting the presence of advanced fibrosis. Methods: Patients were identified using a computer database. Patients responding to initial therapy were compared with patients who did not respond in terms of laboratory and histology parameters. The utility of three fibrosis markers/models were then examined. Results: Thirty-nine patients with AIH were included in this analysis. The mean age was 45.4; 65% of patients were females. Mean ALT at presentation was 268 U/L and AST was 277 U/ L. GGT level was found to be the only statistically significant laboratory or histopathological parameter difference between responders and non-responders. Platelet count and AST/ALT ratio were found to be the best predictors of advanced fibrosis. Conclusion: In Saudi patients with AIH, we found that the GGT level at presentation may serve as a useful predictor for response to therapy. Platelet count and AST/ALT ratio may be used to predict advanced fibrosis.


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