Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2008  |  Volume : 14  |  Issue : 3  |  Page : 118-121

Prevalence and factors affecting occurrence of type 2 diabetes mellitus in Saudi patients with chronic liver disease


1 Division of Gastroenterology, Department of Medicine, King Fahd Central Hospital, Gizan, KSA; James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
2 Division of Gastroenterology, Department of Medicine, King Fahd Central Hospital, Gizan, KSA; Heal Medical Incs, P.O. Box 10096, San Bermardino, CA 92443, USA

Correspondence Address:
Ashwani K Singal
Division of Gastroenterology, Department of Medicine, University of Texas Medical Branch, 301 University Blvd., Galveston, Tx, 77555, USA

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.41729

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Background/Aim: Type 2 diabetes mellitus (DM-2) is more common in patients with chronic liver disease (CLD) in general and chronic hepatitis C virus (HCV) infection in particular. We aimed to determine the prevalence and factors affecting the occurrence of DM-2 in Saudi patients with CLD. Materials and Methods: Retrospective study at the King Fahd Central Hospital (KFCH), Gizan, Saudi Arabia. A total of 277 patients with either cirrhosis (CH) or hepatocellular carcinoma (HCC) were analyzed for patient demographics, severity of liver disease, HBsAg, and anti-HCV, associated diseases including DM-2, and presence of HCC. The prevalence of DM-2 was also estimated in 400 age- and sex-matched Saudi patients admitted for various nonliver diseases (control group). Chi-square test, univariate analysis, and multivariate regression. Results: Prevalence of DM-2 in patients with CH was higher than in controls (19.2 vs. 9.2%; P = 0.001). Although those with HCC had a higher prevalence, the difference was not significant (10.9 vs. 9.2%; P = 0.5). Seventy-six percent of patients with HCC had associated CH. On multivariate analysis, age and hypertension were more common in diabetics. Although patients with HCV-related disease had a higher prevalence of DM-2 compared to HBV-related disease, the difference was not significant (26.3 vs. 15.7%; P > 0.05). Conclusions: DM-2 occurred more frequently in CLD patients, particularly in cirrhotics. Age and hypertension predicted the occurrence of DM-2. Small sample size of patients with HCV-related CH probably precluded higher prevalence of DM-2 in them.


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