Saudi Journal of Gastroenterology
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Year : 2009  |  Volume : 15  |  Issue : 1  |  Page : 72-79

Reversal of liver fibrosis


1 Department of Internal Medicine, Division of Gastroenterology at King Fahad Hospital of the University, Al-Khobar, Saudi Arabia
2 Dipartimento di Medicina Interna-Center for Research, High Education and Transfer "DENOThe"- Universitą degli Studi di Firenze, Florence, Italy

Correspondence Address:
Mona H Ismail
Department of Internal Medicine, Division of Gastroenterology, College of Medicine, King Faisal University-Dammam, King Fahad Hospital of the University, PO Box 40149, Al-Khobar 31952
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.45072

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Hepatic fibrosis is a scarring process associated with an increased and altered deposition of extracellular matrix in the liver. It is caused by a variety of stimuli and if fibrosis continues unopposed, it would progress to cirrhosis which poses a significant health problem worldwide. At the cellular and molecular level, this progressive process is characterized by cellular activation of hepatic stellate cells and aberrant activity of transforming growth factor-β with its downstream cellular mediators. Liver biopsy has been the reference test for assessment of hepatic fibrosis, but because of its limitations, noninvasive markers of liver fibrosis were developed. Liver fibrosis or cirrhosis was considered irreversible in the past but progress of research on the molecular pathogenesis of liver fibrosis has shown that hepatic cellular recovery is possible. Currently, no acceptable therapeutic strategies exist, other than removal of the fibrogenic stimulus, to treat this potentially devastating disease.


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