Saudi Journal of Gastroenterology
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Year : 2009  |  Volume : 15  |  Issue : 4  |  Page : 279-282

Primary lymphoma of the colon


Department of General Surgery, Fr. Muller Medical College Hospital, Kankanady,Mangalore, India

Correspondence Address:
Leo F Tauro
Department of General Surgery, Fr. Muller Medical College Hospital, Kankanady, Mangalore - 575 002
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.56095

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Primary lymphoma of the colon is a rare tumor of the gastrointestinal (GI) tract and comprises only 0.2-1.2% of all colonic malignancies. The most common variety of colonic lymphoma is non-Hodgkin's lymphoma (NHL). The GI tract is the most frequently involved site, accounting for 30-40% of all extra nodal lymphomas, approximately 4-20% of which are NHL. The stomach is the most common location of GI lymphomas, followed by the small intestine. Early diagnosis may prevent intestinal perforation; however, the diagnosis is often delayed in most cases. Therapeutic approaches described in two subsets include: Radical tumor resection (hemicolectomy) plus multi-agent chemotherapy (polychemotherapy) in early stage patients, biopsy plus multidrug chemotherapy in advanced stage patients. Radiotherapy is reserved for specific cases; surgery alone can be considered as an adequate treatment for patients with low-grade NHL disease that does not infiltrate beyond the sub mucosa. Although resection plays an important role in the local control of the disease and in preventing bleeding and/or perforation, it rarely eradicates the lymphoma by itself. Those with limited stage disease may enjoy prolonged survival when treated with aggressive chemotherapy.


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