Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2010  |  Volume : 16  |  Issue : 3  |  Page : 174-180

Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: Effect of exenatide


1 Department of Pharmacology, Smt. R.B.P.M.P.C., Atkot - 360 040, India
2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India

Correspondence Address:
Jitendra D Vaghasiya
Department of Pharmacology, Smt. R.B.P.M.P.C., Atkot - 360 040, Rajkot, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.65187

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Background/Aim: This study was designed to investigate the possible effect of exenatide (Glucagon like Peptide-1 receptor agonist) on liver injury (distant organ) induced by renal ischemia reperfusion (IR) in diabetic rats. Materials and Methods: In vivo renal IR was performed in both type 2 diabetic and normal rats. Each protocol comprised ischemia for 30 minutes followed by reperfusion for 24 hours and a treatment period of 14 days before induction of ischemia. Results: Lipid peroxidation, xanthine oxidase activity, myeloperoxidase activity and nitric oxide level in liver tissue were significantly increased (P < 0.01, P < 0.001, P < 0.001, P < 0.05, respectively), after IR in diabetic rats compared to normal rats. Antioxidant enzymes like glutathione, superoxide dismutase, catalase and glutathione peroxidase were significantly reduced (P < 0.05, P < 0.05, P < 0.01, P < 0.05, respectively), after IR in diabetic rats compared to normal rats. Exenatide treatment significantly normalized (P < 0.01), these biochemical parameters in treated rats compared to diabetic IR rats. Serum creatinine phosphokinase activity and liver function enzymes were also significantly normalized (P < 0.001, P < 0.001, respectively), after administration of exenatide. Conclusion: Exenatide exerted protective effect on exaggerated remote organ (liver) injury induced by renal IR in diabetes.


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