Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2010  |  Volume : 16  |  Issue : 3  |  Page : 194-197

Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change


Department of Drug Applied Research Center, Tabriz University of Medical Sciences, Iran

Correspondence Address:
Sara Farhang
Liver and Gastrointestinal Diseases Research Center, Imam Reza Hospital, Golbad Str; Tabriz, East Azerbaijan
Iran
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Source of Support: Drug Applied Research Center, Tabriz University of Medical Sciences, Conflict of Interest: None


DOI: 10.4103/1319-3767.65197

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Background/Aim: Therapeutic interventions in nonalcoholic fatty liver disease are limited, while anti-oxidative materials have shown benefits in animal models. This study aimed to evaluate grape seed extract as an anti-oxidative material in this process. Therapeutic effects of grape seed extract were evaluated in comparison to vitamin C in a double-blind setting. Materials and Methods: Fifteen patients were enrolled in each group. Liver function tests were done; also, grade of steatosis and pattern of echogenicity of the liver were determined. Patients were followed up by the same evaluation repeated in first, second and third months. Results: Mean age ± standard deviation was 43.2 10.3 years. Grape seed extract (GSE) significantly improved the grade of fatty liver change; and resulted in significant decrease in alanine aminotransferase in patients receiving the concentrate compared to those receiving vitamin C independently, from the initial grade of steatosis. Conclusions: This study describes the beneficial effect of using grape seed extract for three months in patients with nonalcoholic fatty liver disease. These results may improve with a longer period of follow-up.


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