Saudi Journal of Gastroenterology
Home About us Instructions Submission Subscribe Advertise Contact Login    Print this page  Email this page Small font sizeDefault font sizeIncrease font size 
Users Online: 121 


 
Table of Contents   
LETTER TO THE EDITOR  
Year : 2011  |  Volume : 17  |  Issue : 1  |  Page : 84-85
Inefficiency of rapid urease test for confirmation of Helicobacter pylori


1 Department of Bacteriology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2 Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Internal Medicine, Division of Gastroenterology, University Hospital Zurich, Zurich, Switzerland

Click here for correspondence address and email

Date of Web Publication31-Dec-2010
 

How to cite this article:
Bezmin Abadi A, Taghvaei T, Wolfram L. Inefficiency of rapid urease test for confirmation of Helicobacter pylori. Saudi J Gastroenterol 2011;17:84-5

How to cite this URL:
Bezmin Abadi A, Taghvaei T, Wolfram L. Inefficiency of rapid urease test for confirmation of Helicobacter pylori. Saudi J Gastroenterol [serial online] 2011 [cited 2019 May 22];17:84-5. Available from: http://www.saudijgastro.com/text.asp?2011/17/1/84/74441


Sir,

Foroutan et al.[1] published an article entitled "Accuracy of rapid urease test in diagnosing Helicobacter pylori infection in patients using NSAIDs" in the previous volume of Saudi Journal of Gastroenterology. They have investigated the accuracy of rapid urease test (RUT) in Helicobacter pylori strains during the gastroscopy process. In response to their article, we present our contradictory evidences about the efficacy of RUT test as the confirmation of H. pylori isolates in biopsy specimen. Detection of H. pylori in clinical samples is an important subject for clinicians for further management of this rogue microorganism. Routinely, diagnosis tests of H. pylori are divided into two major groups: [2],[3] invasive and noninvasive tests. At this point, we discuss RUT as one of the commonly used noninvasive test, which was applied by Foroutan et al.[1] It was recommended [2],[3] that the presence of H. pylori should be confirmed by using at least any two of thee following methods: RUT, histology, UBT (Urea Breath Test), specific PCR assay, and bacterial culture. Nevertheless, they reported H. pylori-positive strains in their study, while no culture or specific PCR assay were performed in their examination. [1] Our data, supported by other reports from Iran, [4] demonstrate that most of the biopsy specimens from the antrum harbor H. pylori, while their RUT was primarily reported as being negative. Foroutan et al.[1] concluded that the use of NSAID does not affect the RUT test result. In our data [4],[5] we observed that 30% of RUT-negative patients revealed H. pylori strains after culture and specific gene PCR assay. [2] In other words, we showed that of 340 consecutive patients referred for gastroscopy in our clinic, 95 (27%) were RUT negative. [4],[5] This important finding, in contrast to Foroutan et al.[1] study, showed that RUT test does not show a high sensitivity if we perform in a condition with large sample size. In conclusion, we strongly recommended that physicians do not rely on RUT as a test of high sensitivity for test for determination of H. pylori infection.

 
   References Top

1.Foroutan M, Loloei B, Irvani S, Azargashb E. Accuracy of rapid urease test in diagnosing Helicobacter pylori infection in patients using NSAIDs. Saudi J Gastroenterol 2010;16:110-2.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Kusters JG, Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 2006;19:449-90.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.Hirschl A, Makristathis A. Methods to detect Helicobacter pylori: From culture to molecular biology. Helicobacter 2007;12:6-11.  Back to cited text no. 3
    
4.Talebi Bezmin Abadi A, Mohabati Mobarez A, Ajami A, Rafiee A, Taghwaii T. Evaluation on antibiotic resistance of H. pylori isolated from patients admitted to Tooba Medical Center, Sari. J Mazand Univ Med Sci 2009;19:26-32.  Back to cited text no. 4
    
5.Haghi Tomatari F, Mohabati Mobarez A, Amini M, Hosseini D, Talebi Bezmin Abadi A. Helicobacter pylori resistance to metronidazole and clarithromycin in dyspeptic patients in Iran. Iranian Red Crescent Med J 2010;12:409-12.  Back to cited text no. 5
    

Top
Correspondence Address:
Amin Talebi Bezmin Abadi
Department of Bacteriology, School of Medical Sciences, Tarbiat Modares University, Tehran
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.74441

Rights and Permissions




 

Top
  
 
  Search
 
  
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  


    References

 Article Access Statistics
    Viewed1753    
    Printed68    
    Emailed0    
    PDF Downloaded325    
    Comments [Add]    

Recommend this journal