Saudi Journal of Gastroenterology
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CASE REPORT
Year : 2011  |  Volume : 17  |  Issue : 5  |  Page : 353-356

Herpes simplex ulcerative esophagitis in healthy children


1 Department of Pediatrics, Division of Pediatric Gastroenterology, Children's Hospital, Riyadh, Saudi Arabia
2 Department of Pathology, King Fahad Medical City, Riyadh, Saudi Arabia

Correspondence Address:
Abdulrahman A Al-Hussaini
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital, King Fahad Medical City, Riyadh Postal code 11525
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.84496

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Herpes simplex virus is a common cause of ulcerative esophagitis in the immunocompromised or debilitated host. Despite a high prevalence of primary and recurrent Herpes simplex virus infection in the general population, Herpes simplex virus esophagitis (HSVE) appears to be rare in the immunocompetent host. We report three cases of endoscopically-diagnosed HSVE in apparently immunocompetent children; the presentation was characterized by acute onset of fever, odynophagia, and dysphagia. In two cases, the diagnosis was confirmed histologically by identification of herpes viral inclusions and culture of the virus in the presence of inflammation. The third case was considered to have probable HSVE based on the presence of typical cold sore on his lip, typical endoscopic finding, histopathological evidence of inflammation in esophageal biopsies and positive serologic evidence of acute Herpes simplex virus infection. Two cases received an intravenous course of acyclovir and one had self-limited recovery. All three cases had normal immunological workup and excellent health on long-term follow-up.


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