Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2012  |  Volume : 18  |  Issue : 1  |  Page : 55-58

Mucosal invasion by fusobacteria is a common feature of acute appendicitis in Germany, Russia, and China


1 Department of Gastroenterology, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Charité Universitätsmedizin Berlin, CCM, Germany
2 Internal Medicine, Outpatient Clinic, Luisenstrasse 11-13, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany
3 Russian State Medical University, Department of Pathology, Moscow Faculty, Ostrovityanova Steet. 1, 117997 Moscow, Russia
4 Russian State Medical University, Department of Pathology, Moscow Faculty, Ostrovityanova Steet. 1, 117997 Moscow; Department of Pediatrics, Tushinskaya Children's Hospital, Geroev Panfilovtsev Steet. 28, 125480 Moscow, Russian Federation, Russia
5 Department of Pediatrics, Tushinskaya Children's Hospital, Geroev Panfilovtsev Steet. 28, 125480 Moscow, Russian Federation, Russia
6 The State Key Laboratory of Virology 2004DA105204 and Department of Epidemiology, Wuhan University School of Public Health, Wuhan 430071, China
7 Department of Surgery, No. 457 Hospital of People's Liberation Army, Wuhan, Hubei Province, China

Correspondence Address:
Alexander Swidsinski
Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Charité Universitätsmedizin Berlin, Campus Mitte, 10098 Berlin
Germany
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.91734

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Background/Aim: To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis. Patients and Methods: Carnoy- and formalin-fixated appendices from Germany, Russia, and China were comparatively investigated. Bacteria were detected using fluorescent in situ hybridization. Cecal biopsies from patients with inflammatory bowel disease and other conditions were used as disease controls. Results: Fusobacteria represented mainly by Fusobacterium nucleatum were the major invasive component in bacterial infiltrates in acute appendicitis but were completely absent in controls. The occurrence of invasive Fusobacteria in Germany, Russia, and China was the same. The detection rate in Carnoy-fixated material was 70-71% and in formalin-fixated material was 30-36%. Conclusions: Acute appendicitis is a polymicrobial infectious disease in which F. nucleatum and other Fusobacteria play a key role.


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