Saudi Journal of Gastroenterology
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Year : 2012  |  Volume : 18  |  Issue : 3  |  Page : 155-167

Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches


Department of Zoology, Biochemical and Clinical Genetics Research Laboratory, Section of Genetics, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

Correspondence Address:
Riaz Ahmad
Department of Zoology, Biochemical and Clinical Genetics Research Laboratory, Section of Genetics, Aligarh Muslim University, Aligarh- 202 002, Uttar Pradesh
India
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Source of Support: University Grants Commission (UGC) [DS Kothari-PDF], Department of Science & Technology (DST), Ministry of Science & Technology, New Delhi [No. DST/INSPIRE/2010/121], Conflict of Interest: None


DOI: 10.4103/1319-3767.96445

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Hepatic fibrosis (HF) is a progressive condition with serious clinical complications arising from abnormal proliferation and amassing of tough fibrous scar tissue. This defiance of collagen fibers becomes fatal due to ultimate failure of liver functions. Participation of various cell types, interlinked cellular events, and large number of mediator molecules make the fibrotic process enormously complex and dynamic. However, with better appreciation of underlying cellular and molecular mechanisms of fibrosis, the assumption that HF cannot be cured is gradually changing. Recent findings have underlined the therapeutic potential of a number of synthetic compounds as well as plant derivatives for cessation or even the reversal of the processes that transforms the liver into fibrotic tissue. It is expected that future inputs will provide a conceptual framework to develop more specific strategies that would facilitate the assessment of risk factors, shortlist early diagnosis biomarkers, and eventually guide development of effective therapeutic alternatives.


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