Saudi Journal of Gastroenterology
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Year : 2012  |  Volume : 18  |  Issue : 4  |  Page : 225-229

Immunoinflammation and functional gastrointestinal disorders


Department of Gastroenterology, RenMin Hospital of WuHan University, HuBei Province, China

Correspondence Address:
Ming-Kai Chen
RenMin Hospital of WuHan University, 238 Jiefang Road, HuBei Province-430060
China
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Source of Support: This work was supported by the National Natural Science Foundation of China (Key Grant No. 81170350), Conflict of Interest: None


DOI: 10.4103/1319-3767.98420

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Functional gastrointestinal disorders (FGIDs) are a group of conditions characterized by the dysfunction of the gastrointestinal (GI) tract. Although the specific pathogenesis of FGIDs is unclear, several theories have been proposed to explain the symptoms. Abnormal GI motility and visceral hypersensitivity have always been considered to be the main physiopathologic basis of FGIDs, and FGIDs related to psychomental disorders have also caused a major social concern. In recent years, a growing number of researches have proved that cytokines have a significant influence on GI motility, and the role of cytokines in FGIDs has aroused more and more attention. In this article, we discuss the interaction between immunoinflammation and FGIDs, and make an overview of current studies.


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