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SYSTEMATIC REVIEW  
Year : 2012  |  Volume : 18  |  Issue : 5  |  Page : 310-315
Systematic review of diet in the pathogenesis of acute pancreatitis: A tale of too much or too little?


Department of Surgery, Modbury Hospital, South Australia, Australia

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Date of Submission21-Sep-2011
Date of Acceptance29-Mar-2012
Date of Web Publication18-Sep-2012
 

   Abstract 

Background/Aim: The role of diet as the cause of acute pancreatitis (AP) has been suggested. The aim of the current review was to determine if there exists sufficient evidence linking nutrition, or the lack of it, to the pathogenesis of AP. Patients and Methods: A systematic search of the scientific literature was carried out using Embase, PubMed, MEDLINE, and the Cochrane Central Register of Controlled Trials for the years 1965 - 2011 to obtain access to studies involving dietary factors and the pathogenesis of AP. Results: A total of 17 studies were identified describing diet and AP. These included 12 human and 5 animal studies. 8 reports were found to link malnutrition and/or refeeding to the pathogenesis of AP. Two studies found an increased consumption of fats and proteins in patients with alcohol-related AP while 1 study noted a lesser intake of carbohydrate in patients. However, none of these differences attained statistical significance. A recent prospective case-control study found a significantly higher risk for AP amongst patients eating par-boiled rice and fresh water fish. Conclusions: Evidence from literature does not appear to support the role of diet as a single bolus meal as a cause for AP. Prolonged consumption of diets rich in proteins and fats may work synergistically with gallstones / alcohol to trigger an attack of AP indicating a possible role of diet as a cofactor in the development of AP possibly by lowering the threshold needed by these other agents to lead to the attack of AP.

Keywords: Carbohydrates, fats, proteins

How to cite this article:
Thomas T, Mah L, Barreto SG. Systematic review of diet in the pathogenesis of acute pancreatitis: A tale of too much or too little?. Saudi J Gastroenterol 2012;18:310-5

How to cite this URL:
Thomas T, Mah L, Barreto SG. Systematic review of diet in the pathogenesis of acute pancreatitis: A tale of too much or too little?. Saudi J Gastroenterol [serial online] 2012 [cited 2020 Aug 7];18:310-5. Available from: http://www.saudijgastro.com/text.asp?2012/18/5/310/101124


Patients presenting with acute pancreatitis (AP) often report their pain coming on after a large meal or following a period of starvation which may often be associated with an alcohol binge. This suggests a role for diet in the development of AP, a role that has been investigated in animal models [1],[2],[3] as well as in humans. [4],[5],[6] On the other hand, lack of nutrition as well as malnutrition have also been linked to the development of AP. [7],[8] Additionally, the consumption of large quantities of rice [9] and even drinking water [10] have been postulated to cause AP.

The aim of the current study was to determine if there exists sufficient evidence in published literature linking diet, or the lack of it, to the pathogenesis of AP.


   Patients and Methods Top


A systematic search of the scientific literature was carried out using Embase, PubMed, MEDLINE, and the Cochrane Central Register of Controlled Trials for the years 1965 - 2011 to obtain access to all publications, especially randomized controlled trials (RCTs), systematic reviews, and meta-analyses involving dietary factors and the pathogenesis of AP. The search strategy was that described by Dickersin et al. [11] with the appropriate specific search terms, namely, "acute pancreatitis", "proteins", "fats", "carbohydrates", "systematic" and "randomized controlled trials". All available publications from the past 50 years were considered. Inclusion criteria: Studies specifically addressing a pathogenetic role of diet and dietary constituents in the causation of AP.

Exclusion criteria

Studies on the pathogenesis of diet in chronic pancreatitis
Studies pertaining to the dietary aspects in the management of an attack of AP.


   Results Top


Using the above search strategy, a total of 550 publications were retrieved of which 17 studies [Algorithm 1] were identified describing diet in the development of AP. These included 12 human studies (case control and cohort studies, case series and case reports) and 5 animal studies.



Effects of dietary constituents (fats, proteins and carbohydrates)

Animal studies

Experimental studies in murine models have confirmed that diets rich in proteins, carbohydrates and fats stimulate the trypsin, amylase and lipase content of pancreatic tissue, respectively. [12],[13],[14],[15] Wilson et al. [16] found that administering a protein-deficient diet resulted in a reduction in the acinar lipase content in rats, while chronic ethanol consumption increased the lipase content as well as the secretory capacity of the acini. They thus postulated that if it is the enzyme secretory capacity that determines the risk of AP, then in chronic alcoholics, a high protein diet could potentiate an attack of AP. Additionally, lobular and acinar atrophy were noted in monkeys fed protein-deficient diets. [17]

The role of individual dietary constituents, such as fats, proteins and carbohydrates, has been studied in animal models of AP [Table 1]. [1],[2],[3],[18],[19]
Table 1: Animal studies exploring the effect of dietary constituents on AP

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Ramo et al. [3] demonstrated that, histologically, the pancreata of animals fed ethanol and carbohydrate showed the most severe form of AP. This, however, did not correlate with the observed mortality noted amongst animals fed fat- and protein-rich diets. Thus, there is little evidence to suggest carbohydrates have a role in initiating or exacerbating experimental AP.

Human studies

Experimental studies in humans on the role of diet on pancreatic enzyme release have indicated that, in the short term (<14 days), altering the constituent (fats, proteins and carbohydrates) composition in the meal does not induce major changes in enzyme release [20] as was previously noted in animal studies, or more specifically, murine models. However, Boivin et al. [21] have demonstrated that diets rich in proteins and fats, but low in carbohydrates, stimulated the inter-digestive and post-prandial outputs of trypsin and amylase.

The 3 large human studies on the role of nutrition in AP were published prior to 1985.

In the first retrospective study by Sarles et al., [5] comparing nutritional intake amongst 22 patients with AP and two control cohorts, they found no significant difference in nutrient intake (proteins / carbohydrates / and fats) between the AP and the control groups. Although, patients with AP tended to consume fewer carbohydrates than the controls, the difference was not found to be statistically significant (P < 0.067).

Sarles [4] then conducted a large international study involving autopsy patients (n = 681) as well as patients who were administered a dietary questionnaire (n = 205) from all continents. The dietary intake of the cases was compared to national nutritional data. A positive correlation between fats and proteins and AP was found when comparing national nutritional data with autopsy results.

Wilson et al. [6] compared the dietary intake of alcoholic patients with AP and cirrhosis and found that although patients with AP consumed more fat and protein than those patients with cirrhosis, the difference did not reach statistical significance.

Recently, a prospective case-control study from Goa, India [22] looking at the role of diet in the development of AP noted that the consumption of fresh water fish (OR = 3.94, CI =1.63-9.4, P < 0.002) and parboiled rice (OR = 2.10, CI = 1.07-4.13, P < 0.04) was significantly associated with the risk of AP. Other foods such as salt water fish, beef, mutton, chicken, the use of coconut oil and steamed rice had no significant association (P- not significant) with the development of AP.

Malnutrition

Malnutrition has been linked to the development of chronic pancreatitis (CP). [23] The underlying mechanisms for such an association include oxidative damage in a system with poor antioxidant reserves, and inflammatory damage involving interleukin-1, interleukin-6 and tumour necrosis factor-α. This could lead to the activation of pancreatic stellate cells and consequent inflammation and fibrosis. [24] Prolonged periods of malnutrition have been shown experimentally to cause damage to the pancreas. It was demonstrated that Bonnet monkeys fed with a protein deficient diet exhibited lobular and acinar atrophy. [17] This was also noted on autopsy studies on malnourished IBO children, in which acinar atrophy and fibrosis were seen. [25]

In AP, however, the impact of malnutrition is sparse. Anorexia nervosa and bulimia, and even, refeeding after periods of anorexia have been reported to cause AP. [Table 2] provides a review of the cases reported in literature. [7],[26],[27],[28],[29],[30],[31],[32] Cox et al., [34] however, pointed out an association between protein calorie malnutrition and abnormalities in pancreatic enzyme levels in the serum being misconceived as AP.
Table 2: Studies on the role of malnutrition and refeeding in the causation of AP (Modified and updated from Morris et al.[7])

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Refeeding

Refeeding after a prolonged period of starvation has also been linked to the development of AP. Based on the studies by Gryboski et al. [30] and Keane et al. [28] it has been suggested that refeeding worsens gastric dilatation and duodenal ileus which is associated with anorexia nervosa leading to retrograde pressure and reflux of duodenal contents into the pancreatic duct triggering off an attack of AP. Although these are the only two studies specifically addressing refeeding following anorexia, the development of pain following refeeding even in patients with AP due to other causes who were fasted owing to their presentation has been well appreciated over the years. [35] Pain in this setting has been reported to be due to re-stimulation of the pancreatic secretion by oral bolus feeding, which may activate dormant enzymes and the inflammatory process. [36]


   Discussion Top


In summary, the above studies indicate that dietary constituents do affect pancreatic enzyme output. In animals, this may be noted as an acute phenomenon. However, in humans, a prolonged exposure to a diet rich in protein and fats appears to alter enzyme levels in the pancreas. In terms of the dietary factors and their association with the risk of developing AP, human studies have indicated that diet may play a role. However, there is no conclusive evidence of direct causative role although the evidence supports the role for diet as a co-factor to other agents (alcohol, gallstones). Animal studies certainly provide possible mechanisms as to how this may happen.

The role of diet in the development of AP has often been considered. The problem with the large human studies [4],[5],[6] examining such an association is that they were published prior to 1985. The incidence of obesity has dramatically increased the world over since then. [37] Besides, obesity is a low grade pro-inflammatory state. [38] Obesity contributes to the generation of mediators potentially involved in the induction of the systemic inflammatory response. [39]

Hong et al. [40] recently analysed the relationship between a high body mass index and the risk of developing AP as well as the risk of morbidity and found that obesity is not only associated with an increased risk of AP development, but it is also a poor prognostic factor for AP.

What is also fascinating is that at the other end of the spectrum, malnutrition has also been linked to the development of AP. [7]

In terms of human studies exploring the dietary constituents, the only study examining such a role in AP found an increased relative risk for AP amongst people who ate par-boiled rice and fresh water fish. [22] The significance of these findings was not elucidated. This study supports the paper by Chen [9] who hypothesized that the repeated consumption of large quantities of rice could predispose to the development of AP over a period of time. Chen [9] postulated the development of changes occurring in the  Sphincter of Oddi More Details following repeated consumption of large boluses of rice and proteins which empty into the duodenum and overstimulate the sphincter, resulting in oedema. These findings although apparently contradictory to the findings of Sarles et al. [5] indicating that the subjects with AP tended to consume smaller quantities of carbohydrates, may provide an important difference in the pattern of consumption of rice in the two continents.

In the case of malnutrition, the human and animal studies indicate that it is the lack of adequate quantities of dietary constituents that induce a change in the pancreatic exocrine architecture as well as possible changes in the oxidant and antioxidant balance over a period of time. Despite there existing a temporal association between malnutrition and AP, the available data appears insufficient to suggest an aetiological role for malnutrition in the development of AP. It can only be hypothesized that a reduction in the release of enzymes over prolonged periods of malnutrition may result in a potential down-regulation in the intra pancreatic protective mechanisms, such as pancreatic secretory trypsin inhibitor (PSTI). This may make an individual susceptible to other potential triggers by lowering the threshold for the achievement of the 'critical mass'. [41] Alternatively, a sudden change in the dietary intake with the introduction of a nutrient-rich meal may result in a surge in the enzymes released which could potentially overwhelm the existing protective mechanisms resulting in an attack of AP. In the event that an association between malnutrition and AP does prove to exist based on future studies, one potential mechanism that could contribute to the development of AP would be oxidative stress. [42],[43]

Clues to the mechanism of development of AP by high protein or fat diets come from the animal studies. In animal studies, adding triglycerides to the perfusate of ex vivo pancreata harvested from rats in whom AP was induced, resulted in an increase in the amylase and lipase levels in the portal venous effluent. [44] Similarly, changes consistent with AP were induced in ex vivo, perfused canine pancreata when triglycerides or free fatty acids were added to the perfusate. [45] Using an in vivo model, it was shown that high and very high levels of dietary unsaturated fats potentiated the harmful effects of ethanol consumption on the pancreas. [46] Zhang et al. [47] found that chronic high fat diet increased pancreatic free fatty acids and lipid peroxidation associated with pancreatic injuries and collagen synthesis by activated pancreatic stellate cells in rats. It has been consistently shown that high protein and fat diets potentiate the severity of experimentally-induced AP in animals. [1],[2],[3],[18],[19] Contrary to the above studies, Sarles et al. [48] found that the administration of different diets to rats fed on ethanol produced changes in the pancreas no different to those fed on water. However, there have been no studies that have shown high protein or fat diets actually cause AP by themselves. Although we have pointed out earlier that obesity has emerged as a serious problem the world over and obese individuals are at an increased risk of developing AP, to date there are no studies correlating the food consumed by obese individuals found to have a high risk of AP and the actual risk of development of the disease. Such a study would, thus, seem prudent as it would aid in health education in this group of patients besides corroborating the mechanisms of disease pathogenesis that has been elucidated in some of the animal studies.


   Conclusion Top


In conclusion, evidence from literature does not appear to support the role of diet as a single bolus meal as a cause for AP. Prolonged consumption of diets rich in proteins and fats may work synergistically with gallstones / alcohol to trigger an attack of AP indicating a possible role of diet as a cofactor in the causation of AP possibly by lowering the threshold needed by these other agents to lead to the attack of AP.

 
   References Top

1.Maki T, Kakizaki G, Sato T, Saito Y, Suda Y. Effect of diet on experimental pancreatitis in rat. Tohoku J Exp Med 1967;92:301-9.  Back to cited text no. 1
[PUBMED]    
2.Ramo OJ. Antecedent long term ethanol consumption in combination with different diets alters the severity of experimental acute pancreatitis in rats. Gut 1987;28:64-9.  Back to cited text no. 2
    
3.Ramo OJ, Apaja-Sarkkinen M, Jalovaara P. Experimental acute pancreatitis in rats receiving different diets and ethanol. Correlation between histological findings and mortality. Res Exp Med (Berl) 1987;187:33-41.  Back to cited text no. 3
    
4.Sarles H. An international survey on nutrition and pancreatitis. Digestion 1973;9:389-403.  Back to cited text no. 4
[PUBMED]    
5.Sarles H, Sarles JC, Camatte R, Muratore R, Gaini N, Guien C, et al. Observations on 205 confirmed cases of acute pancreatitis, recurring pancreatitis, and chronic pancreatitis. Gut 1965;6:545-59.  Back to cited text no. 5
    
6.Wilson JS, Bernstein L, McDonald C, Tait A, McNeil D, Pirola RC. Diet and drinking habits in relation to the development of alcoholic pancreatitis. Gut 1985;26:882-7.  Back to cited text no. 6
[PUBMED]    
7.Morris LG, Stephenson KE, Herring S, Marti JL. Recurrent acute pancreatitis in anorexia and bulimia. JOP 2004;5:231-4.  Back to cited text no. 7
[PUBMED]    
8.Reddymasu S, Banks DE, Jordan PA. Acute pancreatitis in a patient with malnutrition due to major depressive disorder. Am J Med 2006;119:179-80.  Back to cited text no. 8
[PUBMED]    
9.Chen MC. Diet-induced pancreatitis in China. J Clin Gastroenterol 1986;8:611-2.  Back to cited text no. 9
[PUBMED]    
10.Giggs JA, Bourke JB, Katschinski B. The epidemiology of primary acute pancreatitis in Greater Nottingham: 1969-1983. Soc Sci Med 1988;26:79-89.  Back to cited text no. 10
[PUBMED]    
11.Dickersin K, Scherer R, Lefebvre C. Identifying relevant studies for systematic reviews. BMJ 1994;309:1286-91.  Back to cited text no. 11
[PUBMED]    
12.Chowdhury P, Nishikawa M, Blevins GW Jr, Rayford PL. Response of rat exocrine pancreas to high-fat and high-carbohydrate diets. Proc Soc Exp Biol Med 2000;223:310-5.  Back to cited text no. 12
[PUBMED]    
13.Howard F, Yudkin J. Effect of dietary change upon the amylase and trypsin activities of the rat pancreas. Br J Nutr 1963;17:281-94.  Back to cited text no. 13
[PUBMED]    
14.Johnson A, Hurwitz R, Kretchmer N. Adaptation of rat pancreatic amylase and chymotrypsinogen to changes in diet. J Nutr 1977;107:87-96.  Back to cited text no. 14
[PUBMED]    
15.Schick J, Verspohl R, Kern H, Scheele G. Two distinct adaptive responses in the synthesis of exocrine pancreatic enzymes to inverse changes in protein and carbohydrate in the diet. Am J Physiol 1984;247:G611-6.  Back to cited text no. 15
[PUBMED]    
16.Wilson JS, Korsten MA, Leo MA, Lieber CS. Combined effects of protein deficiency and chronic ethanol consumption on rat pancreas. Dig Dis Sci 1988;33:1250-9.  Back to cited text no. 16
[PUBMED]    
17.Sandhyamani S, Vijayakumari A, Balaraman Nair M. Bonnet monkey model for pancreatic changes in induced malnutrition. Pancreas 1999;18:84-95.  Back to cited text no. 17
[PUBMED]    
18.Brian Haig TH. Experimental pancreatitis intensified by a high fat diet. Surg Gynecol Obstet 1970;131:914-8.  Back to cited text no. 18
[PUBMED]    
19.Czako L, Szabolcs A, Vajda A, Csati S, Venglovecz V, Rakonczay Z Jr, et al. Hyperlipidemia induced by a cholesterol-rich diet aggravates necrotizing pancreatitis in rats. Eur J Pharmacol 2007;572:74-81.  Back to cited text no. 19
    
20.Emde C, Liehr RM, Gregor M, Pleul O, Riecken EO, Menge H. Lack of adaptive changes in human pancreatic amylase and lipase secretion in response to high-carbohydrate, low-fat diet applied by a 10-day continuous intraduodenal infusion. Dig Dis Sci 1985;30:204-10.  Back to cited text no. 20
[PUBMED]    
21.Boivin M, Lanspa SJ, Zinsmeister AR, Go VL, DiMagno EP. Are diets associated with different rates of human inter digestive and postprandial pancreatic enzyme secretion? Gastroenterology 1990;99:1763-71.  Back to cited text no. 21
[PUBMED]    
22.Mitta N, Barreto SG, Rodrigues J. Dietary risk factors for acute pancreatitis: A case-control study. Surg Chronicles 2011;16:186-7.  Back to cited text no. 22
    
23.Barman KK, Premalatha G, Mohan V. Tropical chronic pancreatitis. Postgrad Med J 2003;79:606-15.  Back to cited text no. 23
[PUBMED]    
24.Wesson RN, Sparaco A, Smith MD. Chronic pancreatitis in a patient with malnutrition due to anorexia nervosa. JOP 2008;9:327-31.  Back to cited text no. 24
[PUBMED]    
25.Montalegre A, Sarles H, Ricosse JH, Sahel J. Pancreatic lesions due to prolonged malnutrition in Ibo children: Possible transition between kwashiorkor and chronic calcifying pancreatitis. Pancreas 1987;2:114-6.  Back to cited text no. 25
[PUBMED]    
26.Wright JG, Swiontkowski MF, Heckman JD. Introducing levels of evidence to the journal. J Bone Joint Surg Am 2003;85-A:1-3.  Back to cited text no. 26
[PUBMED]    
27.Nordgren L, von Scheele C. Hepatic and pancreatic dysfunction in anorexia nervosa: A report of two cases. Biol Psychiatry 1977;12:681-6.  Back to cited text no. 27
    
28.Keane FB, Fennell JS, Tomkin GH. Acute pancreatitis, acute gastric dilation and duodenal ileus following refeeding in anorexia nervosa. Ir J Med Sci 1978;147:191-2.  Back to cited text no. 28
[PUBMED]    
29.Schoettle UC. Pancreatitis: A complication, a concomitant, or a cause of an anorexia nervosalike syndrome. J Am Acad Child Psychiatry 1979;18:384-90.  Back to cited text no. 29
[PUBMED]    
30.Gryboski J, Hillemeier C, Kocoshis S, Anyan W, Seashore JS. Refeeding pancreatitis in malnourished children. J Pediatr 1980;97:441-3.  Back to cited text no. 30
[PUBMED]    
31.Rampling D. Acute pancreatitis in anorexia nervosa. Med J Aust 1982;2:194-5.  Back to cited text no. 31
[PUBMED]    
32.Backett SA. Acute pancreatitis and gastric dilatation in a patient with anorexia nervosa. Postgrad Med J 1985;61:39-40.  Back to cited text no. 32
[PUBMED]    
33.Gwee K, Teh A, Huang C. Acute superior mesenteric artery syndrome and pancreatitis in anorexia nervosa. Australas Psychiatry 2010;18:523-6.  Back to cited text no. 33
[PUBMED]    
34.Cox KL, Cannon RA, Ament ME, Phillips HE, Schaffer CB. Biochemical and ultrasonic abnormalities of the pancreas in anorexia nervosa. Dig Dis Sci 1983;28:225-9.  Back to cited text no. 34
[PUBMED]    
35.Petrov MS, van Santvoort HC, Besselink MG, Cirkel GA, Brink MA, Gooszen HG. Oral refeeding after onset of acute pancreatitis: A review of literature. Am J Gastroenterol 2007;102:2079-84; quiz 2085.  Back to cited text no. 35
[PUBMED]    
36.Frossard JL, Hadengue A. Acute pancreatitis: New physiopathological concepts. Gastroenterol Clin Biol 2001;25:164-76.  Back to cited text no. 36
[PUBMED]    
37.Massiera F, Barbry P, Guesnet P, Joly A, Luquet S, Moreilhon-Brest C, et al. A western-like fat diet is sufficient to induce a gradual enhancement in fat mass over generations. J Lipid Res 2010;51:2352-61.  Back to cited text no. 37
[PUBMED]    
38.O'Rourke RW. Inflammation in obesity-related diseases. Surgery 2009;145:255-9.  Back to cited text no. 38
[PUBMED]    
39.Franco-Pons N, Gea-Sorli S, Closa D. Release of inflammatory mediators by adipose tissue during acute pancreatitis. J Pathol 2010;221:175-82.  Back to cited text no. 39
    
40.Hong S, Qiwen B, Ying J, Wei A, Chaoyang T. Body mass index and the risk and prognosis of acute pancreatitis: A meta-analysis. Eur J Gastroenterol Hepatol 2011 [Epub].  Back to cited text no. 40
    
41.Barreto SG, Saccone GT. Alcohol-induced acute pancreatitis: The 'critical mass' concept. Med Hypotheses 2010;75:73-6.  Back to cited text no. 41
[PUBMED]    
42.Braganza JM, Scott P, Bilton D, Schofield D, Chaloner C, Shiel N, et al. Evidence for early oxidative stress in acute pancreatitis. Clues for correction. Int J Pancreatol 1995;17:69-81.  Back to cited text no. 42
[PUBMED]    
43.Schulz HU, Niederau C, Klonowski-Stumpe H, Halangk W, Luthen R, Lippert H. Oxidative stress in acute pancreatitis. Hepatogastroenterology 1999;46:2736-50.  Back to cited text no. 43
[PUBMED]    
44.Kimura W, Mossner J. Role of hypertriglyceridemia in the pathogenesis of experimental acute pancreatitis in rats. Int J Pancreatol 1996;20:177-84.  Back to cited text no. 44
    
45.Saharia P, Margolis S, Zuidema GD, Cameron JL. Acute pancreatitis with hyperlipemia: Studies with an isolated perfused canine pancreas. Surgery 1977;82:60-7.  Back to cited text no. 45
[PUBMED]    
46.Tsukamoto H, Towner SJ, Yu GS, French SW. Potentiation of ethanol-induced pancreatic injury by dietary fat. Induction of chronic pancreatitis by alcohol in rats. Am J Pathol 1988;131:246-57.  Back to cited text no. 46
[PUBMED]    
47.Zhang X, Cui Y, Fang L, Li F. Chronic high-fat diets induce oxide injuries and fibro genesis of pancreatic cells in rats. Pancreas 2008;37:e31-8.  Back to cited text no. 47
[PUBMED]    
48.Sarles H, Figarella C, Clemente F. The interaction of ethanol, dietary lipids, and proteins on the rat pancreas. I. Pancreatic enzymes. Digestion 1971;4:13-22.  Back to cited text no. 48
    

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Correspondence Address:
Savio G Barreto
Department of Surgery, Modbury Hospital, South Australia, 5092
Australia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.101124

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    Tables

  [Table 1], [Table 2]

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