Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2012  |  Volume : 18  |  Issue : 6  |  Page : 375-379

Persistent oxidative stress in patients with chronic active hepatitis-C infection after antiviral therapy failure


1 Department of Internal Medicine, Faculty of Medicine, Mansoura University, Egypt
2 Department of Tropical Medicine, Faculty of Medicine, Mansoura University, Egypt
3 Department of Clinical Pathology Faculty of Medicine, Mansoura University, Egypt
4 Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt

Correspondence Address:
Ghada El-Kannishy
Department of Internal Medicine, Faculty of Medicine, Endocrinology Unit, Mansoura University Hospital, Mansoura
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.103429

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Background/Aims: Oxidative stress and hepatocellular pathological changes are common associations with chronic hepatitis C virus (CHC) disease. The aim of this study was to assess serum antioxidant-oxidant (Redox) balance in patients with CHC infection before and after intake of the traditional antiviral therapy (pegylated interferon α-2b and oral ribavirin). Patients and Methods : Blood samples from 50 biopsy-proven CHC patients, with no prior anti-viral treatment and persistently elevated serum transaminase levels for 6 months, as well as 15 age- and sex-matched healthy subjects were used for determination of the antioxidants: reduced glutathione (GSH), superoxide dismutase (SOD), α tocopherol and ascorbic acid as well as lipid peroxidation (LPO) index (malondialdehyde [MDA]). The measurements were repeated in the diseased group 25 weeks after pegylated interferon α-2b and ribavirin combination therapy. Results : Serum levels of bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly higher in CHC patients than in the control group (P < 0.05). Pretreatment serum MDA values were significantly higher in patients with CHC infection than the control group (P < 0.001), while serum antioxidant levels were significantly lower (P < 0.001). Responders (10 patients) had lower pretreatment serum levels of MDA than non-responders (35 patients) (P < 0.001). Both groups were comparable for the antioxidant serum levels. There was significant negative correlation between serum MDA and serum SOD, GSH, α tocopherol, and ascorbic acid concentrations in CHC patients. On the other hand, there was no correlation between the studied parameters and serum bilirubin, albumin, ALT, and AST. Conclusions : Redox imbalance was detected in patients with CHC. Responders had significantly lower levels of MDA than non-responders. Serum MDA may be used as a pretreatment predictor of response to antiviral treatment in patients with CHC.


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