Saudi Journal of Gastroenterology
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CASE REPORT
Year : 2013  |  Volume : 19  |  Issue : 5  |  Page : 235-237

Propafenone hepatotoxicity: Report of a new case and review of the literature


1 Department of Internal Medicine, Divisions of Gastroenterology and Hepatology, and Cardiology, American University of Beirut Medical Center, Beirut, Lebanon
2 Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon
3 Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon

Correspondence Address:
Mohamad A Eloubeidi
Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236 Riad El Solh 110 72020 Beirut
Lebanon
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.118137

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Propafenone is a class Ic antiarrhythmic drug. It is a beta-adrenergic blocker that causes bradycardia and bronchospasm. It is metabolized primarily in the liver. Its bioavailability and plasma concentration differ among patients under long-term therapy. They are genetically determined by the hepatic cytochrome P-450 2D6. Hepatic toxicity is highly uncommon. To date, only eight patients were reported in the reviewed world literature. In this article, one new case will be reported emphasizing the importance of medication history taking in patients presenting with new-onset liver enzymes abnormalities.


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