Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2015  |  Volume : 21  |  Issue : 2  |  Page : 84-89

Mannose-binding lectin gene polymorphism and chronic hepatitis B infection in children


1 Department of Pediatric Gastroenterology, Hepatology and Nutrition, Uludag University Medical Faculty, Bursa, Turkey
2 Department of Microbiology, Uludag University Medical Faculty, Bursa, Turkey
3 Department of Pediatric Immunology, Uludag University Medical Faculty, Bursa, Turkey
4 Department of Genetics, Ege University Medical Faculty, Izmir, Turkey

Correspondence Address:
Dr. Gulin Erdemir
Uludag University Medical Faculty, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Bursa
Turkey
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Source of Support: Uludag University Scientific Research Projects, grant UAP (T)-2009/32,, Conflict of Interest: None


DOI: 10.4103/1319-3767.153825

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Background/Aims: Mannose-binding lectin (MBL) is a member of innate immune system that activates complement system through lectin pathway. MBL deficiency is associated with susceptibility to infectious diseases. In this study, the relation between MBL gene polymorphism and chronic hepatitis B infection in children is evaluated. Patients and Methods: The study included 67 children with chronic hepatitis B and 99 healthy controls. The hepatitis B patients were divided into immuntolerant, chronic inactive, and treatment groups according to their laboratory findings. MBL gene codon 52, 54, and 57 polymorphisms were studied with polymerase chain reaction in all patients and controls. The associations of MBL gene polymorphism with clinical, laboratory, and histopathologic findings were evaluated. Results: Homozygous codon 54 polymorphism of MBL was found significantly higher in chronic hepatitis B patients than controls. Rate of the polymorphism was similar in all groups and, responsive and nonresponsive patients in the treatment group. Conclusions: The hepatitis B patients who are homozygous for codon 54 of MBL are prone to develop chronic infection. Longitudinal studies with larger groups are needed.


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