| ORIGINAL ARTICLE |
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| Year : 2015 | Volume
: 21
| Issue : 6 | Page : 355-359 |
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Two-week triple therapy has a higher Helicobacter pylori eradication rate than 1-week therapy: A single-center randomized study
Jiaofeng Wang1, Gansheng Zhang2, Xiaona Hu2, Ye Liu3, Zhijun Bao2, Yiqin Huang2
1 Department of Geriatrics, Huadong Hospital, Shanghai, China
2 Department of Gastroenterology, Huadong Hospital, Shanghai, China
3 Department of Basic Medicine, Medical School of Shanghai, Fudan University, Shanghai, China
Correspondence Address:
Dr. Yiqin Huang
Department of Gastroenterology, Huadong Hospital affiliated to Fudan University, Shanghai 200040
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1319-3767.170951
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Background and Aim: To evaluate a high effective and practical regimen for the eradication of Helicobacter pylori infection. Patients and Methods: The 298 patients with H. pylori infection, diagnosed by biopsies performed during the endoscopy, were randomized into two groups. Group 1: Treated for one week with a combination of omeprazole, amoxicillin, and clarithromycin (OAC), named by OAC-1 group (n = 143); Group 2: OAC-2 group (n = 155) treated for two weeks with OAC. The OAC-1 group was treated with triple therapy of omeprazole 20 mg, amoxicillin 1000 mg, and clarithromycin 500 mg bid for 1 week. OAC-2 group was treated likewise, but for two weeks. A 13C-urea breath test was used to monitorH. pylori after four to eight weeks following therapy. Results: The eradication of infection was 55% and 68% in the OAC-1 and OAC-2 groups, respectively. Moreover, the eradication rates in the two groups were 63% and 75%, respectively. Compared with the OAC-1 group, the efficacy of treatment in the OAC-2 group is significantly higher (P < 0.05). Conclusion: Two-week OAC regimen yields a higher eradication rate of H. pylori, which might be a practical regimen for the eradication of H. pylori. |
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