Saudi Journal of Gastroenterology
Home About us Instructions Submission Subscribe Advertise Contact Login    Print this page  Email this page Small font sizeDefault font sizeIncrease font size 
Users Online: 1903 
REVIEW ARTICLE
Year : 2016  |  Volume : 22  |  Issue : 1  |  Page : 3-17

The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models


1 Department of Biology, Alexandru Ioan Cuza University, Bulevardul Carol, Iaşi, Romania
2 Department of Biology, Alexandru Ioan Cuza University, Bulevardul Carol, Iaşi; Department of Animal Physiology, Center of Biomedical Research of the Romanian Academy, Iaşi, Romania
3 Department of Gastroenterology, "Gr. T. Popa" University of Medicine and Pharmacy, Iaşi, Romania
4 Department of Animal Physiology, Center of Biomedical Research of the Romanian Academy, Iaşi, Romania

Correspondence Address:
Dr. Alin Ciobica
Department of Biology, Alexandru Ioan Cuza University, Bulevardul Carol I, 11, Iaşi - 700506
Romania
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.173753

Rights and Permissions

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder characterized by alternating phases of clinical relapse and remission. The etiology of IBD remains largely unknown, although a combination of patient's immune response, genetics, microbiome, and environment plays an important role in disturbing intestinal homeostasis, leading to development and perpetuation of the inflammatory cascade in IBD. As chronic intestinal inflammation is associated with the formation of reactive oxygen and reactive nitrogen species (ROS and RNS), oxidative and nitrosative stress has been proposed as one of the major contributing factor in the IBD development. Substantial evidence suggests that IBD is associated with an imbalance between increased ROS and decreased antioxidant activity, which may explain, at least in part, many of the clinical pathophysiological features of both CD and UC patients. Hereby, we review the presently known oxidant and antioxidant mechanisms involved in IBD-specific events, the animal models used to determine these specific features, and also the antioxidant therapies proposed in IBD patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4288    
    Printed49    
    Emailed0    
    PDF Downloaded896    
    Comments [Add]    

Recommend this journal