Saudi Journal of Gastroenterology
Home About us Instructions Ahead of print Submission Subscribe Advertise Contact Login    Print this page  Email this page Small font sizeDefault font sizeIncrease font size 
Users Online: 63 
SYSTEMATIC REVIEW/META ANALYSIS
Year : 2017  |  Volume : 23  |  Issue : 2  |  Page : 82-90

Comparison of diagnostic efficacy between AFI, NBI, and AFI combined with NBI for colonic cancers: A meta-analysis


Department of Gastroenterology, West Hospital of Sichuan University, Sichuan, China

Correspondence Address:
Yan Xie
No. 37 Guo Xue Xiang, Chengdu, Sichuan - 610041
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.203355

Rights and Permissions

Background/Aims: Advanced endoscopic imaging technologies have been used for the early detection and differentiation of colonic cancers recently. We aim to evaluate the diagnostic efficacy of autofluorescence imaging (AFI), narrow-band imaging (NBI), and AFI combined with NBI for colonic cancers. Materials and Methods: We searched Medline/PubMed, Embase, Web of Science, and Cochrane Library databases for relevant articles. A random-effects model was used to assess diagnostic efficacy. Heterogeneity was tested by the I2 statistic and Chi-square test. Meta-regression was used to analyze the sources of heterogeneity. Results: The pooled sensitivities for AFI, NBI, and AFI plus NBI were 0.84 (95% confidence interval (CI) 0.82–0.87), 0.84 (95% CI 0.81–0.86), and 0.93 (95% CI 0.90–0.95), respectively. The pooled specificities were 0.44 (95% CI 0.40–0.48), 0.69 (95% CI 0.65–0.72), and 0.69 (95% CI 0.64–0.74), respectively. The sensitivity estimate was significantly higher for AFI plus NBI than AFI or NBI alone (P = 0.041), and the specificity estimates were significantly higher for NBI and AFI plus NBI than AFI (P = 0.031).The pooled diagnostic odds ratio for AFI, NBI, and AFI plus NBI were 8.71 (95% CI 2.90–26.16), 16.02 (95% CI 7.05–36.39), and 57.55 (95% CI 9.82–337.33), respectively. Furthermore, the summary receiver operating characteristic curve area under the curve for AFI, NBI, and AFI plus NBI were 0.8125 with Q* =0.7469, 0.8696 with Q* =0.8001, and 0.9447 with Q* =0.8835, respectively. The Q* index for AFI plus NBI was significantly higher than AFI or NBI alone (P = 0.048). Conclusion: The combination of AFI and NBI was associated with increased diagnostic value for colonic cancers compared with AFI and NBI alone.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed675    
    Printed19    
    Emailed0    
    PDF Downloaded105    
    Comments [Add]    

Recommend this journal