Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2017  |  Volume : 23  |  Issue : 6  |  Page : 348-356

Validity and clinical impact of glucose transporter 1 expression in colorectal cancer


1 Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt
2 Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt
3 Department of Clinical Oncology, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt

Correspondence Address:
Suzy F Gohar
Department of Clinical Oncology, Faculty of Medicine, Menoufia University, Shibin El Kom
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjg.SJG_197_17

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Background/Aim: There is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis still remains an irritating question with no definite answer. Being a fundamental player in cancer metabolism, glucose transporter 1 (GLUT1) could be utilized as a prognostic biomarker that could fuel development of new treatment strategies. The aim of this study was to assess the validity of GLUT1 expression as a prognostic biomarker and to elucidate to what extent it is immersed in poor clinical outcome among CRC patients. Patients and Methods: GLUT1 expression in peripheral blood specimens was analyzed by quantitative real-time polymerase chain reaction in 47 CRC patients and 20 healthy controls. Results: There was significantly elevated GLUT1 expression in peripheral blood of CRC patients than in controls (P < 0.001). The cutoff value of 0.605 provided 98% sensitivity and 100% specificity. There were significantly higher values of GLUT1 expression in patients under 50 years (P = 0.003), performance status 2 (P = 0.009), stage IV (P < 0.001), and presence of metastasis (P < 0.001). GLUT1 expression showed nonsignificant association with overall survival (P = 0.068), while tumor stage (P = 0.01) and metastasis (P = 0.009) were significantly associated with lower overall survival. Conclusion: GLUT1 is sensitive and specific marker for CRC. It is overexpressed in young age patients, poor performance status, and stage IV patients. Although this was not statistically significant, GLUT 1 showed higher expression level in patients with lesser survival.


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