Saudi Journal of Gastroenterology
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SYSTEMATIC REVIEW/META ANALYSIS
Year : 2018  |  Volume : 24  |  Issue : 4  |  Page : 201-210

Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis


1 Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University. (Guangdong Gastrointestinal Hospital), Guangzhou, Guangdong, People's Republic of China
2 Department of Endoscopy, The Sixth Affiliated Hospital of Sun Yat-sen University. (Guangdong Gastrointestinal Hospital), Guangzhou, Guangdong, People's Republic of China
3 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University. (Guangdong Gastrointestinal Hospital), Guangzhou, Guangdong, People's Republic of China
4 Department of Gastroenterology; Department of Clinical Nutrition, The Sixth Affiliated Hospital of Sun Yat-sen University. (Guangdong Gastrointestinal Hospital); Guangdong Gastrointestinal Institutes, Guangzhou, Guangdong, People's Republic of China

Correspondence Address:
Dr. Qing He
Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen, University (Guangdong Gastrointestinal Hospital), Guangzhou, Guangdong,
People's Republic of China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjg.SJG_5_18

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Background/Aims: Three extensively investigated polymorphisms (rs3810936, rs7848647, and rs6478108) in tumor necrosis factor super family member 15 (TNFSF15) gene have been implicated in risk for inflammatory bowel disease (IBD). We performed a quantitative synthesis of the evidence to clarify these associations of TNFSF15 polymorphisms with IBD. Materials and Methods: Data were extracted from PubMed and EMBASE, up to March 15, 2018. Meta-analysis was performed by critically reviewing five studies for rs3810936 polymorphism (2251 cases and 2442 controls), four studies for rs7848647 polymorphism (1503 cases and 1816 controls), and four studies for rs6478108 polymorphism (1502 cases and 1817 controls). Results: Our analysis suggested that rs3810936 polymorphism was significantly associated with decreased risk of Crohn's disease (CD) and ulcerative colitis (UC). For rs7848647 polymorphism, significantly protective association between this polymorphism and CD risk was also observed, but not in UC. For rs6478108 polymorphism, we also detected a significantly protective association with CD risk in all genetic model but not in UC. Conclusions: This meta-analysis suggests that TNFSF15 polymorphisms may contribute to genetic susceptibility of IBD.


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