Saudi Journal of Gastroenterology
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Year : 2019  |  Volume : 25  |  Issue : 3  |  Page : 145-151

The regulatory roles of long noncoding RNAs in the biological behavior of pancreatic cancer


1 Department of Blood Transfusion, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
2 Department of Operating Room, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
3 Department of Gastroenterological Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China

Correspondence Address:
Dr. Shanglong Liu
Department of Gastroenterological Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, P. R
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjg.SJG_465_18

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Long noncoding RNAs (lncRNAs) are a new class of regulators. LncRNAs are defined as endogenous transcribed RNA molecules with transcript length of >200 nt. Accumulating evidence has shown that lncRNAs are involved in many physiological processes such as cell cycle regulation, cell apoptosis and survival, cancer migration and metabolism. However, the biological and molecular mechanisms of lncRNAs in pancreatic cancer are still unclear. Recent studies have reported that many lncRNAs are dysregulated in pancreatic cancer and closely associated with tumorigenesis, diagnosis and prognosis. In this review, we described the regulation and functional role of lncRNAs and the potential underlying mechanism involved in pancreatic cancer, outlined the roles of lncRNA in pancreatic cancer, and discussed the potential possibility of lncRNAs as therapeutic targets in clinical practice. Moreover, the potential of lncRNAs used as sensitive biomarkers for diagnosis, prognosis and prediction of response to therapy in pancreatic cancer will also be discussed.


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