Saudi Journal of Gastroenterology
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SYSTEMATIC REVIEW/META ANALYSIS
Year : 2020  |  Volume : 26  |  Issue : 3  |  Page : 113-119

Endoscopic ultrasound versus computed tomography in determining the resectability of pancreatic cancer: A diagnostic test accuracy meta-analysis


1 Division of Gastroenterology, McMaster University, Hamilton, Canada
2 Department of Medicine, Queen's University, Kingston, Ontario, Canada
3 Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada
4 Division of Gastroenterology; Department of Health Research Methods, Evidence and Impact; GI Health Technology Assessment Group, The Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada

Correspondence Address:
Dr. Mohammad Yaghoobi
Division of Gastroenterology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1
Canada
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjg.SJG_39_20

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Background/Aim: Endoscopic ultrasound (EUS) and contrast-enhanced computed tomography (CT) with pancreas protocol are used in assessing the resectability of neoplastic pancreatic lesions. Here, we performed a diagnostic test accuracy (DTA) meta-analysis, comparing the diagnostic accuracy of EUS and CT in evaluating the resectability of pancreatic cancer using surgical assessment as the reference standard. Patients and Methods: A comprehensive electronic search was conducted up to March 2020. Studies comparing EUS and CT in assessing the resectability of pancreatic cancer using surgical assessment as reference standard were included. QUADAS-2 tool was used to assess the quality of the included studies. After data extraction, an analysis was done using DerSimonian Laird method (random-effects model) to estimate the overall diagnostic odds ratio (DOR) and determine the best-fitting receiver operating characteristics (ROC) curve. Results: Two studies, with 77 subjects combined, were included in the analysis. Overall, the risk of bias was moderate. EUS and CT were comparable in determining the resectability of pancreatic cancer with AUC = 75% (95% confidence interval (CI) 66%- 84%) for EUS as compared to 78% (95% CI 69%- 87%) for CT (P > 0.05). Pooled sensitivity and specificity was 87% (95% CI 70%- 96%) and 63% (95% CI 48%- 77%), respectively for EUS and 87% (95% CI 70%- 96%) and 70% (95% CI 55%- 83%), respectively for CT. DOR was 11.51 (95% CI 3.55- 36.81) for EUS as compared to 15.91 (95% CI 4.83- 51.62) for CT (P > 0.05). Conclusions: Both EUS and CT provide reasonable sensitivity and specificity to detect the resectability of pancreatic cancer.


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