Saudi Journal of Gastroenterology
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SYSTEMATIC REVIEW/META ANALYSIS
Year : 2020  |  Volume : 26  |  Issue : 4  |  Page : 171-178

The association between SNPs rs1800591 and rs3816873 of the MTTP gene and nonalcoholic fatty liver disease: A meta-analysis


1 Weifang Medical University, Weifang; Department of Infectious Disease, Qingdao Municipal Hospital, Qingdao, China
2 Department of Infectious Disease, Qingdao Municipal Hospital, Qingdao, China
3 Hepatology Laboratory, Qingdao Municipal Hospital; Digestive Disease Key Laboratory of Qingdao, Qingdao, China
4 Medical College of Qingdao University, Qingdao, China
5 Department of Infectious Disease; Hepatology Laboratory, Qingdao Municipal Hospital; Digestive Disease Key Laboratory of Qingdao, Qingdao, China

Correspondence Address:
Prof. Yongning Xin
Department of Infectious Disease, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao 266011, Shandong Province
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjg.SJG_201_20

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Background/Aims: The role of two polymorphisms rs1800591 and rs3816873 of the microsomal triglyceride transfer protein (MTTP) gene in the development of nonalcoholic fatty liver disease (NAFLD) remains controversial. A meta-analysis was conducted to determine the correlation between these MTTP polymorphisms and NAFLD. Materials and Methods: A systematic search was carried out using PubMed, Embase, and Cochrane Library to retrieve English studies that reported the relationship between MTTP polymorphisms (rs1800591 and rs3816873) and NAFLD published before February 18, 2020. Odds ratio (OR) and 95% confidence interval (CI) were used to appraise the risk of MTTP polymorphism in NAFLD. Results: A total of 10 case-control studies, including 1388 cases and 1690 healthy subjects, were included. No significant correlation between the rs1800591 (G vs. T: OR = 1.08, 95% CI = 0.68–1.70, P = 0.76) and rs3816873 (CT + CC vs. TT: OR = 1.23, 95% CI = 0.76–2.01, P = 0.398) polymorphisms of MTTP and NAFLD was found in any of the models. However, when NASH patients confirmed by liver biopsy were extracted alone for rs1800591 polymorphism analysis, it was found that the G allele significantly increased the risk of NASH under the heterozygote model (GT vs. TT: OR = 3.16, 95% CI = 1.13–8.83, P = 0.028) and dominant model (GT + GG vs. TT: OR = 3.03, 95% CI = 1.13–8.09, P = 0.027). Conclusion: The present meta-analysis revealed that the rs1800591 and rs3816873 polymorphisms of the MTTP gene are uncommon in NAFLD. However, the G allele of rs1800591 was more likely to be correlated to NASH susceptibility.


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