Saudi Journal of Gastroenterology
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SYSTEMATIC REVIEW/META ANALYSIS
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A meta-analysis of early oral refeeding and quickly increased diet for patients with mild acute pancreatitis


1 Department of Emergency, Clinical Medical College of Yangzhou University, Subei People's Hospital, Yangzhou 225001, Jiangsu Province, China
2 Department of Operating Room, Clinical Medical College of Yangzhou University, Subei People's Hospital, Yangzhou 225001, Jiangsu Province, China

Correspondence Address:
Jiyang Xu,
Clinical Medical College of Yangzhou University, Subei People's Hospital, Nantong West Road, 98Yangzhou 225001, Jiangsu Province
China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sjg.SJG_240_18

PMID: 30226482

Background/Aim: The objective of the study is to clarify whether early oral refeeding (EORF) and quickly increasing diet (QID) are of benefit to patients with mild acute pancreatitis compared with a traditional oral refeeding strategy. Materials and Methods: Studies were searched in PubMed, Cochrane library, ScienceDirect, SpringerLink, China Biology Medicine disc and Embase. A meta-analysis was then performed, using relapse of abdominal pain, nausea/vomiting, and length of hospital stay (LOHS) as the evaluation indices. Results: Eight trials met the inclusion criteria. For the oral refeeding time group, EORF could significantly decrease the LOHS (mean deviation [MD] −1.97; 95% confidence interval (CI) −3.32 to −0.62;P = 0.004), and there was no significant difference for relapse of abdominal pain (relative risk [RR] 1.17; 95% CI 0.69–2.00;P = 0.56) or nausea/vomiting (RR 1.30; 95% CI 0.19–8.82;P = 0.79) when compared with conventional oral refeeding. For the oral refeeding material group, there was no significant difference for relapse of abdominal pain (RR 0.86; 95% CI 0.53–1.40;P = 0.54), nausea/vomiting (risk difference −0.01; 95% CI −0.19–0.18;P = 0.94), or LOHS (MD −0.88; 95% CI −2.24–0.48;P = 0.20) between the QID and stepwise increasing diet groups. Conclusion: Pure EORF or QID caused no damage to patients with mild acute pancreatitis, and EORF could significantly decrease the LOHS.


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    -  Zhu S
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