Saudi Journal of Gastroenterology

REVIEW ARTICLE
Year
: 1999  |  Volume : 5  |  Issue : 2  |  Page : 50--55

Hepatitis G virus (HGV) and liver diseases


Sami Ramia1, Faleh Zaid Al Faleh2 
1 Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
2 Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Faleh Zaid Al Faleh
Department of Medicine (38), College of Medicine, King Saud University, P.O. Box. 2925, Riyadh 11461
Saudi Arabia

Recently, a new flavi-like virus, provisionally named hepatitis GBV-C or hepatitis G virus (HGV), has been described and was initially thought to be the major etiological agent of non-A-E hepatitis. HGV does not induce an immune response that is consistently detectable by using recombinant proteins from prokaryotic expression and hence prevalence studies have been conducted by using polymerase chain reaction (PCR)-based system. HGV-RNA has been detected in many human populations. This article reviews what has been investigated about HGV from normal blood donors, patients with liver disease, patients at risk of acquiring the infection to possible perinatal and sexual transmission of the virus. Based on the conclusions that can be drawn from these studies conducted so far, the association between HGV infection and liver disease is still not certain. It is possible that HGV might play a role in other diseases not involving the liver, but at the present time HGV can be considered as an orphan flavivirus still looking for a human disease.


How to cite this article:
Ramia S, Al Faleh FZ. Hepatitis G virus (HGV) and liver diseases.Saudi J Gastroenterol 1999;5:50-55


How to cite this URL:
Ramia S, Al Faleh FZ. Hepatitis G virus (HGV) and liver diseases. Saudi J Gastroenterol [serial online] 1999 [cited 2020 Jul 14 ];5:50-55
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=1999;volume=5;issue=2;spage=50;epage=55;aulast=Ramia;type=0