Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2008  |  Volume : 14  |  Issue : 3  |  Page : 118--121

Prevalence and factors affecting occurrence of type 2 diabetes mellitus in Saudi patients with chronic liver disease


Ashwani K Singal1, Ayobanji E Ayoola2 
1 Division of Gastroenterology, Department of Medicine, King Fahd Central Hospital, Gizan, KSA; James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
2 Division of Gastroenterology, Department of Medicine, King Fahd Central Hospital, Gizan, KSA; Heal Medical Incs, P.O. Box 10096, San Bermardino, CA 92443, USA

Correspondence Address:
Ashwani K Singal
Division of Gastroenterology, Department of Medicine, University of Texas Medical Branch, 301 University Blvd., Galveston, Tx, 77555, USA

Background/Aim: Type 2 diabetes mellitus (DM-2) is more common in patients with chronic liver disease (CLD) in general and chronic hepatitis C virus (HCV) infection in particular. We aimed to determine the prevalence and factors affecting the occurrence of DM-2 in Saudi patients with CLD. Materials and Methods: Retrospective study at the King Fahd Central Hospital (KFCH), Gizan, Saudi Arabia. A total of 277 patients with either cirrhosis (CH) or hepatocellular carcinoma (HCC) were analyzed for patient demographics, severity of liver disease, HBsAg, and anti-HCV, associated diseases including DM-2, and presence of HCC. The prevalence of DM-2 was also estimated in 400 age- and sex-matched Saudi patients admitted for various nonliver diseases (control group). Chi-square test, univariate analysis, and multivariate regression. Results: Prevalence of DM-2 in patients with CH was higher than in controls (19.2 vs. 9.2%; P = 0.001). Although those with HCC had a higher prevalence, the difference was not significant (10.9 vs. 9.2%; P = 0.5). Seventy-six percent of patients with HCC had associated CH. On multivariate analysis, age and hypertension were more common in diabetics. Although patients with HCV-related disease had a higher prevalence of DM-2 compared to HBV-related disease, the difference was not significant (26.3 vs. 15.7%; P > 0.05). Conclusions: DM-2 occurred more frequently in CLD patients, particularly in cirrhotics. Age and hypertension predicted the occurrence of DM-2. Small sample size of patients with HCV-related CH probably precluded higher prevalence of DM-2 in them.


How to cite this article:
Singal AK, Ayoola AE. Prevalence and factors affecting occurrence of type 2 diabetes mellitus in Saudi patients with chronic liver disease.Saudi J Gastroenterol 2008;14:118-121


How to cite this URL:
Singal AK, Ayoola AE. Prevalence and factors affecting occurrence of type 2 diabetes mellitus in Saudi patients with chronic liver disease. Saudi J Gastroenterol [serial online] 2008 [cited 2020 Jan 18 ];14:118-121
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2008;volume=14;issue=3;spage=118;epage=121;aulast=Singal;type=0