Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 16  |  Issue : 3  |  Page : 174--180

Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: Effect of exenatide


Jitendra D Vaghasiya1, Navin R Sheth2, Yagnik S Bhalodia1, Nurudin P Jivani1 
1 Department of Pharmacology, Smt. R.B.P.M.P.C., Atkot - 360 040, India
2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India

Correspondence Address:
Jitendra D Vaghasiya
Department of Pharmacology, Smt. R.B.P.M.P.C., Atkot - 360 040, Rajkot, Gujarat
India

Background/Aim: This study was designed to investigate the possible effect of exenatide (Glucagon like Peptide-1 receptor agonist) on liver injury (distant organ) induced by renal ischemia reperfusion (IR) in diabetic rats. Materials and Methods: In vivo renal IR was performed in both type 2 diabetic and normal rats. Each protocol comprised ischemia for 30 minutes followed by reperfusion for 24 hours and a treatment period of 14 days before induction of ischemia. Results: Lipid peroxidation, xanthine oxidase activity, myeloperoxidase activity and nitric oxide level in liver tissue were significantly increased (P < 0.01, P < 0.001, P < 0.001, P < 0.05, respectively), after IR in diabetic rats compared to normal rats. Antioxidant enzymes like glutathione, superoxide dismutase, catalase and glutathione peroxidase were significantly reduced (P < 0.05, P < 0.05, P < 0.01, P < 0.05, respectively), after IR in diabetic rats compared to normal rats. Exenatide treatment significantly normalized (P < 0.01), these biochemical parameters in treated rats compared to diabetic IR rats. Serum creatinine phosphokinase activity and liver function enzymes were also significantly normalized (P < 0.001, P < 0.001, respectively), after administration of exenatide. Conclusion: Exenatide exerted protective effect on exaggerated remote organ (liver) injury induced by renal IR in diabetes.


How to cite this article:
Vaghasiya JD, Sheth NR, Bhalodia YS, Jivani NP. Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: Effect of exenatide.Saudi J Gastroenterol 2010;16:174-180


How to cite this URL:
Vaghasiya JD, Sheth NR, Bhalodia YS, Jivani NP. Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: Effect of exenatide. Saudi J Gastroenterol [serial online] 2010 [cited 2020 Aug 9 ];16:174-180
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2010;volume=16;issue=3;spage=174;epage=180;aulast=Vaghasiya;type=0