Saudi Journal of Gastroenterology

CASE REPORT
Year
: 2011  |  Volume : 17  |  Issue : 5  |  Page : 348--352

Concurrent autoimmune hepatitis and grave«SQ»s disease in Hepatitis C during pegylated Interferon α-2a and ribavirin therapy


Guru V Trikudanathan1, Imad Ahmad1, Jonathan L Israel2 
1 Department of Internal Medicine, University of Connecticut Medical Center, Farmington, USA
2 Division of Gastroenterology, Hartford Hospital, Hartford, CT, USA

Correspondence Address:
Jonathan L Israel
Division of Gastroenterology, Hartford Hospital, 85 Seymour Street, Suite 1000, CT-06106
USA

Classical interferon-α has been shown to be associated with the development of a variety of autoimmune disorders. A 34-year-old white woman with chronic hepatitis C virus infection who was treated with pegylated interferon α-2a and ribavirin, developed Grave«SQ»s disease and autoimmune hepatitis (AIH) at 32 and 44 weeks, respectively, following initiation of the therapy. The diagnosis of AIH was made based on the new development of anti-smooth muscle antibodies, anti-mitochondrial antibodies, and liver biopsy findings. It was confirmed by positive response to steroid challenge and was assessed according to the international AIH scoring system. Based on the previous case reports, we review the existing literature. Clinicians should be aware of the possibility of multiple autoimmune disorders during interferon-based therapy for chronic hepatitis.


How to cite this article:
Trikudanathan GV, Ahmad I, Israel JL. Concurrent autoimmune hepatitis and grave's disease in Hepatitis C during pegylated Interferon α-2a and ribavirin therapy.Saudi J Gastroenterol 2011;17:348-352


How to cite this URL:
Trikudanathan GV, Ahmad I, Israel JL. Concurrent autoimmune hepatitis and grave's disease in Hepatitis C during pegylated Interferon α-2a and ribavirin therapy. Saudi J Gastroenterol [serial online] 2011 [cited 2020 Aug 11 ];17:348-352
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2011;volume=17;issue=5;spage=348;epage=352;aulast=Trikudanathan;type=0