Saudi Journal of Gastroenterology

CASE REPORT
Year
: 2012  |  Volume : 18  |  Issue : 4  |  Page : 277--281

Fatal hepatitis B reactivation treated with entecavir in an isolated anti-HBs positive lymphoma patient: A case report and literature review


Rosa Ferreira, Joana Carvalheiro, Joana Torres, Alexandra Fernandes, Sílvia Giestas, Sofia Mendes, Cláudia Agostinho, Mário J Campos 
 Department of Gastroenterology, Hospital Center of Coimbra, Coimbra, Portugal

Correspondence Address:
Rosa Ferreira
Hospital Center of Coimbra, Gastroenterology Department, Quinta dos Vales, São Martinho do Bispo, 3046-853 Coimbra
Portugal

Hepatitis B virus (HBV) reactivation is a well-recognized complication that occurs in lymphoma patients who undergo chemotherapy. Only very few cases of HBV reactivation in patients with isolated antibody against hepatitis B surface antigen (anti-HBs) have been reported. We present a case of a 78-year-old woman diagnosed with diffuse large B cell non-Hodgkin«SQ»s lymphoma who only displayed a positive anti-HBs, as the single possible marker of occult HBV infection, before starting therapy. She was treated with several chemotherapeutic regimens (including rituximab) for disease relapses during 3 years. Forty days after the last cycle of chemotherapy, she presented with jaundice, markedly elevated serum aminotransferase levels, and coagulopathy. HBV serology showed positivity for HBsAg, anti-HBc and anti-HBs. HBV DNA was positive. Antiviral treatment with entecavir was promptly initiated, but the patient died from liver failure. A review of the literature of HBV reactivation in patients with detectable anti-HBs levels is discussed.


How to cite this article:
Ferreira R, Carvalheiro J, Torres J, Fernandes A, Giestas S, Mendes S, Agostinho C, Campos MJ. Fatal hepatitis B reactivation treated with entecavir in an isolated anti-HBs positive lymphoma patient: A case report and literature review.Saudi J Gastroenterol 2012;18:277-281


How to cite this URL:
Ferreira R, Carvalheiro J, Torres J, Fernandes A, Giestas S, Mendes S, Agostinho C, Campos MJ. Fatal hepatitis B reactivation treated with entecavir in an isolated anti-HBs positive lymphoma patient: A case report and literature review. Saudi J Gastroenterol [serial online] 2012 [cited 2019 Dec 15 ];18:277-281
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2012;volume=18;issue=4;spage=277;epage=281;aulast=Ferreira;type=0