Saudi Journal of Gastroenterology

CASE REPORT
Year
: 2013  |  Volume : 19  |  Issue : 5  |  Page : 235--237

Propafenone hepatotoxicity: Report of a new case and review of the literature


Lara B Younan1, Kassem A Barada1, Walid G Faraj2, Ayman N Tawil3, Mark N Jabbour3, Maurice Y Khoury1, Nadim MW El-Majzoub3, Mohamad A Eloubeidi1 
1 Department of Internal Medicine, Divisions of Gastroenterology and Hepatology, and Cardiology, American University of Beirut Medical Center, Beirut, Lebanon
2 Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon
3 Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon

Correspondence Address:
Mohamad A Eloubeidi
Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236 Riad El Solh 110 72020 Beirut
Lebanon

Propafenone is a class Ic antiarrhythmic drug. It is a beta-adrenergic blocker that causes bradycardia and bronchospasm. It is metabolized primarily in the liver. Its bioavailability and plasma concentration differ among patients under long-term therapy. They are genetically determined by the hepatic cytochrome P-450 2D6. Hepatic toxicity is highly uncommon. To date, only eight patients were reported in the reviewed world literature. In this article, one new case will be reported emphasizing the importance of medication history taking in patients presenting with new-onset liver enzymes abnormalities.


How to cite this article:
Younan LB, Barada KA, Faraj WG, Tawil AN, Jabbour MN, Khoury MY, El-Majzoub NM, Eloubeidi MA. Propafenone hepatotoxicity: Report of a new case and review of the literature.Saudi J Gastroenterol 2013;19:235-237


How to cite this URL:
Younan LB, Barada KA, Faraj WG, Tawil AN, Jabbour MN, Khoury MY, El-Majzoub NM, Eloubeidi MA. Propafenone hepatotoxicity: Report of a new case and review of the literature. Saudi J Gastroenterol [serial online] 2013 [cited 2020 Jun 6 ];19:235-237
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2013;volume=19;issue=5;spage=235;epage=237;aulast=Younan;type=0