Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 22  |  Issue : 6  |  Page : 448--455

Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice


Wen-feng Zhang, Yan Yang, Xin Su, Da-yan Xu, Yu-li Yan, Qiao Gao, Ming-hua Duan 
 Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road 1035, Changchun, Jilin, China

Correspondence Address:
Ming-hua Duan
Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road
China

Background/Aims: Deoxyschizandrin as one of the most important component of Schisandra chinensis (Turcz.) Baill plays an immunomodulatory role in a variety of diseases, yet its role in ulcerative colitis remains to be elucidated. We aimed to investigate the role of deoxyschizandrin in DSS-induced ulcerative colitis in mice. Patients and Methods: In the present study, an inflammation model of cells was constructed to confirm the anti-inflammatory effect of deoxyschizandrin. Then a mouse model with Dextran sulfate sodium sulfate (DSS)-induced ulcerative colitis was constructed, and the effects of deoxyschizandrin on mouse colon inflammation, apoptosis, and CD4 T lymphocyte infiltration in ulcerative colitis were examined. Result: Deoxyschizandrin could improve the symptoms of ulcerative colitis, determined by hematoxylin-eosin (HE) staining and histopathological scores. Moreover, deoxyschizandrin reduced the levels of inflammatory cytokines, suppressed CD4 T cell infiltration, and effectively inhibited apoptosis in the colon of DSS-induced ulcerative colitis mice. Conclusion: In summary, deoxyschizandrin can effectively rescue the symptoms of DSS-induced ulcerative colitis in mice by inhibiting inflammation. T cell infiltration and apoptosis in the colon, suggesting that deoxyschizandrin could be a potential drug in treating ulcerative colitis.


How to cite this article:
Zhang Wf, Yang Y, Su X, Xu Dy, Yan Yl, Gao Q, Duan Mh. Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice.Saudi J Gastroenterol 2016;22:448-455


How to cite this URL:
Zhang Wf, Yang Y, Su X, Xu Dy, Yan Yl, Gao Q, Duan Mh. Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice. Saudi J Gastroenterol [serial online] 2016 [cited 2020 Sep 26 ];22:448-455
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=6;spage=448;epage=455;aulast=Zhang;type=0