Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 24  |  Issue : 3  |  Page : 165--170

Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection


Zhi-Gang Sun1, Li Yu2, Wei Gao3, Zhou Wang4, Liang-Ming Zhu1 
1 Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, China
2 Department of Otorhinolaryngology, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, China
3 Department of Pathology, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, China
4 Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China

Correspondence Address:
Dr. Liang-Ming Zhu
Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan - 250013, Shandong Province
China

Background/Aim: To investigate the clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma (ESCC) after radical resection. Materials and Methods: A total of 108 ESCC specimens were evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect MUC1 at the mRNA level and were evaluated by immunohistochemistry (IHC) to detect MUC1 at the protein level. Results: MUC1 mRNA was found in 74 cases by RT-PCR and MUC1 protein expression was found by IHC in 70 cases. Both MUC1 mRNA and protein expression correlated with pT (<0.05), pN (P < 0.01), and pTNM (<0.01). The 5-year survival rates of the patients were 39.8%. In univariate analysis, the 5-year survival rate in the ESCC patients was significantly associated with pT (P < 0.01), pN (P < 0.01), pTNM stage (P < 0.01), and MUC1 mRNA and protein expression (P < 0.05). In multivariate analysis, pN and MUC1 expression were the independent relevant factors. Conclusion: MUC1 expression can become a useful marker to predict poor prognostic factors for 5-year survival rate in patients with ESCC after radical resection.


How to cite this article:
Sun ZG, Yu L, Gao W, Wang Z, Zhu LM. Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection.Saudi J Gastroenterol 2018;24:165-170


How to cite this URL:
Sun ZG, Yu L, Gao W, Wang Z, Zhu LM. Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection. Saudi J Gastroenterol [serial online] 2018 [cited 2020 Feb 17 ];24:165-170
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=3;spage=165;epage=170;aulast=Sun;type=0