Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 24  |  Issue : 6  |  Page : 317--325

Radiofrequency ablation versus surgical resection in elderly patients with early-stage hepatocellular carcinoma in the era of organ shortage


Bin Yu1, Youming Ding1, Xiaofeng Liao2, Changhua Wang3, Bin Wang1, Xiaoyan Chen1 
1 Department of Hepatobiliary and Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, China
2 Department of General Surgery, Xiangyang Central Hospital, Xiangyang, China
3 Department of Pathology and Pathophysiology, Wuhan University School of Basic Medical Sciences, Wuhan, China

Correspondence Address:
Prof. Youming Ding
Department of Hepatobiliary and Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province
China

Background/Aims: To compare the survival benefits of surgical resection (SR) with those of radiofrequency ablation (RFA) in elderly patients (≥65 years) with single hepatocellular carcinoma (HCC) ≤5 cm. Patients and Methods: Using the Surveillance, Epidemiology, and End Results database, a total of 461 patients who underwent SR and 575 patients who underwent RFA were enrolled from 2004 to 2012. Overall survival (OS) and liver-cancer-specific survival (LCSS) comparisons were conducted between the two groups before and after propensity score matching (PSM).Results: Elderly patients with early-stage HCC had a lower rate of utilization of liver transplantation, and they were more likely to receive SR or RFA as their first-line treatment compared with younger patients (P < 0.05). In the whole cohort, the SR group had significantly better OS [RFA, hazard ratio (HR) = 1.680 (1.390, 2.031), P < 0.001] and LCSS (RFA, HR = 1.658 (1.327, 2.070), P < 0.001) than the RFA group. After PSM, the improved survival in the SR group was further confirmed (all P < 0.001). In the subgroup analyses, according to patients' age (65–75, >75 years) and tumor size (≤3.0, 3.1–5.0 cm), the SR group still presented better OS and LCSS than the RFA group (all P < 0.05), except for those older than 75 years with tumors ≤3.0 cm (all P > 0.05), both before and after PSM. Conclusion: Treatment strategies for elderly patients (≥65 years) with single HCC ≤5 cm should emphasize SR as the primary therapy, while RFA can be an alternative to SR for those >75 years with single HCC ≤3 cm.


How to cite this article:
Yu B, Ding Y, Liao X, Wang C, Wang B, Chen X. Radiofrequency ablation versus surgical resection in elderly patients with early-stage hepatocellular carcinoma in the era of organ shortage.Saudi J Gastroenterol 2018;24:317-325


How to cite this URL:
Yu B, Ding Y, Liao X, Wang C, Wang B, Chen X. Radiofrequency ablation versus surgical resection in elderly patients with early-stage hepatocellular carcinoma in the era of organ shortage. Saudi J Gastroenterol [serial online] 2018 [cited 2018 Dec 9 ];24:317-325
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=6;spage=317;epage=325;aulast=Yu;type=0