Saudi Journal of Gastroenterology

SYSTEMATIC REVIEW AND META-ANALYSIS
Year
: 2019  |  Volume : 25  |  Issue : 2  |  Page : 81--88

Comparison of long-term efficacy between endoscopic and percutaneous biliary drainage for resectable extrahepatic cholangiocarcinoma with biliary obstruction: A systematic review and meta-analysis


Lei Wang1, Nanping Lin2, Fuli Xin2, Yongyi Zeng4, Jingfeng Liu3 
1 Department of Radiation Oncology; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, China
2 The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province; Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University; Liver Diseases Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China
3 The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University; Liver Diseases Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China

Correspondence Address:
Dr. Jingfeng Liu
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025; Liver Diseases Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350007, Fujian, PR, Xihong Road 312, Fuzhou 350 005, Fujian, PR
China
Dr. Yongyi Zeng
Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Liver Diseases Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350007; Xihong Road 312, Fuzhou 350 005, Fujian, PR
China

Background/Aim: For resectable extrahepatic cholangiocarcinoma with biliary obstruction, it remains a controversy whether to choose percutaneous transhepatic biliary drainage (PTBD) or endoscopic biliary drainage (EBD). A systematic review was conducted to compare the long-term efficacy between the two techniques. Materials and Methods: Eligible studies were searched from January 1990 to May 2018, comparing the long-term efficacy between EBD and PTBD for extrahepatic cholangiocarcinoma. Primary end point was overall survival (OS) rate, and secondary end points included postoperative severe complications and seeding metastasis. Effect size on outcomes was calculated using a fixed- or random-effect model, accompanied with hazard ratio (HR) and 95% confidence interval (CI). Result: Six studies were included in this meta-analysis. Meta-analysis showed that EBD was superior to PTBD in OS (HR = 0.70, 95% CI 0.59–0.84,P= 0.0002). But subgroup results showed that the superiority disappeared in distal cholangiocarcinoma (HR = 0.76, 95% CI 0.56–1.01,P= 0.06). Other prognostic factors such as intraoperative blood transfusion, lymphatic metastasis and seeding metastasis, were inconsistent between groups. In addition, regional disparity was obviously apparent between Japanese and non-Japanese studies. Conclusion: The conclusion that EBD was superior to PTBD in OS for resectable extrahepatic cholangiocarcinoma with biliary obstruction is less convincing, and more trials need to be conducted in future.


How to cite this article:
Wang L, Lin N, Xin F, Zeng Y, Liu J. Comparison of long-term efficacy between endoscopic and percutaneous biliary drainage for resectable extrahepatic cholangiocarcinoma with biliary obstruction: A systematic review and meta-analysis.Saudi J Gastroenterol 2019;25:81-88


How to cite this URL:
Wang L, Lin N, Xin F, Zeng Y, Liu J. Comparison of long-term efficacy between endoscopic and percutaneous biliary drainage for resectable extrahepatic cholangiocarcinoma with biliary obstruction: A systematic review and meta-analysis. Saudi J Gastroenterol [serial online] 2019 [cited 2019 Jul 17 ];25:81-88
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2019;volume=25;issue=2;spage=81;epage=88;aulast=Wang;type=0