SYSTEMATIC REVIEW/META ANALYSIS
Year : 2019 | Volume
: 25 | Issue : 4 | Page : 218--228
The effect of using simethicone with or without N-acetylcysteine before gastroscopy: A meta-analysis and systemic review
Yuanfa Li1, Fangjuan Du2, Dou Fu3
1 Department of Gastroenterology, Xiantao First People's Hospital, China
2 Department of Gastroenterology, Liaocheng Second People's Hospital, China
3 Internal Medicine, Xiantao First People's Hospital, China
Background/Aim: To assess the efficacy and safety of simethicone with or without N-acetylcysteine (NAC) as premedications before gastroscopy.
Materials and Methods: We searched EMBASE, PubMed, Cochrane library and Web of Science database for randomized clinical controlled trials regarding simethicone ± NAC as oral drinking agents before gastroscopy. Statistical software RevMan5.3 was used for statistical analysis.
Results: Ten randomized clinical trials that fulfilled the inclusion criteria were further pooled into a meta-analysis, which included 5,750 patients. The rate of positive findings in simethicone plus NAC group was higher than that in water group (risk ratio [RR] =1.31, 95%CI: 1.12–1.53, P = 0.0006) with high level of evidence. There was no significant difference on the rate of positive findings when comparing simethicone with simethicone plus NAC (RR = 1.02, 95%CI: 0.90–1.16, P = 0.71) and with water (RR = 1.13, 95%CI: 0.82–1.55, P = 0.46), respectively. Simethicone plus NAC showed better total mucosal visibility score than simethicone alone (MD = −0.14 (−0.25, −0.03), P = 0.01) without obvious heterogeneity. Both simethicone plus NAC and simethicone alone offer more benefit than water. The procedure time in simethicone group was shorter than that in water group (MD = −1.23 (−1.51, −0.96), P < 0.00001). Regarding adverse events, there was no significant difference in simethicone and water group (RR = 0.45, 95%CI: 0.2–1.0, P = 0.05, I2 = 0%).
Conclusions: As premedication of gastroscopy, simethicone plus NAC offers more benefit on positive findings and total mucosal visibility score.
Dr. Yuanfa Li
No. 29, Mianzhoudadao Road, Sha Zui District Xiantao City, Hubei Province
|How to cite this article:|
Li Y, Du F, Fu D. The effect of using simethicone with or without N-acetylcysteine before gastroscopy: A meta-analysis and systemic review.Saudi J Gastroenterol 2019;25:218-228
|How to cite this URL:|
Li Y, Du F, Fu D. The effect of using simethicone with or without N-acetylcysteine before gastroscopy: A meta-analysis and systemic review. Saudi J Gastroenterol [serial online] 2019 [cited 2019 Sep 23 ];25:218-228
Available from: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2019;volume=25;issue=4;spage=218;epage=228;aulast=Li;type=0