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  Indian J Med Microbiol
 

Figure 1: Early causes and mechanisms of matrix degradation and progression of hepatic fibrosis. Stimulation of Kupffer cells, neutrophils, and T-cells cause secretion of various cytokines and profibrotic mediator to convert quiescent to activated hepatic stellate cells (HSCs). HSCs are associated with matrix degradation due to increased production of membrane type matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2, -3 (MMP-2, -3), and tissue inhibitors of metalloproteinases (TIMPs), leading to amassing of scar tissue

Figure 1: Early causes and mechanisms of matrix degradation and progression of hepatic fibrosis. Stimulation of Kupffer cells, neutrophils, and T-cells cause secretion of various cytokines and profibrotic mediator to convert quiescent to activated hepatic stellate cells (HSCs). HSCs are associated with matrix degradation due to increased production of membrane type matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2, -3 (MMP-2, -3), and tissue inhibitors of metalloproteinases (TIMPs), leading to amassing of scar tissue