Saudi Journal of Gastroenterology
Home About us Instructions Submission Subscribe Advertise Contact Login    Print this page  Email this page Small font sizeDefault font sizeIncrease font size 
Users Online: 426 


 
LETTER TO EDITOR Table of Contents   
Year : 2007  |  Volume : 13  |  Issue : 2  |  Page : 102
Authors' reply


College of Medicine, Qassim University, Gastroenterology Division, Internal Medicine Department, P.O 6040, Buraidah 5142, Saudi Arabia

Click here for correspondence address and email
 

How to cite this article:
Al-Jarallah B. Authors' reply. Saudi J Gastroenterol 2007;13:102

How to cite this URL:
Al-Jarallah B. Authors' reply. Saudi J Gastroenterol [serial online] 2007 [cited 2020 Oct 27];13:102. Available from: https://www.saudijgastro.com/text.asp?2007/13/2/102/32189


Sir,

I read with interest the letter written by Saeed and Mohamed regarding the prevalence of hepatitis B (HBV) genotypes in Saudi Arabia. The information they presented is certainly most useful and relevant. I agree with the authors that the most common hepatitis B genotypes in Saudi Arabia are genotype D followed by E. This has been recently shown in an epidemiological study designed to address this aspect, which was published in November 2006. [1] The study showed that genotype D is encountered in 81% of the HBV population, followed by genotype E at 5.1%. Ten percent of the patients had mixed genotypes. Although the study intended to look for epidemiological and outcome effects of the various genotypes, it was hard to draw any conclusions due to the limited number of patients from nongenotype D strains. Similarly, no information is currently available on the effect of HBV genotype D on response to antiviral therapy in Saudi Arabia although international literature suggests that the response to pegylated interferons may be inferior to that of other genotypes. [2],[3]

Finally, I support the idea that this topic requires further detailed large epidemiological studies.

 
   References Top

1.Abdo AA, Al-Jarallah BM, Sanai FM, Hersi AS, Al-Swat K, Azzam NA, et al . Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia. World J Gastroenterol 2006;12:7019-24.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Lau GK, Piratvisuth T, Luo KX, Marcellin P, Thongsawat S, Cooksley G, et al . Peginterferon Alfa-2a, lamivudine and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med 2005;352:2682-95.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Marcellin P, Lau GK, Bonino F, Farci P, Hadziyannis S, Jin R, et al . Peginterferon alfa-2a alone, lamivudine alone and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2004;35:1206-17.  Back to cited text no. 3    

Top
Correspondence Address:
Badr Al-Jarallah
College of Medicine, Qassim University, Gastroenterology Division, Internal Medicine Department, P.O 6040, Buraidah 5142
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.32189

Rights and Permissions




 

Top
 
  Search
 
  
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  


    References

 Article Access Statistics
    Viewed2041    
    Printed116    
    Emailed0    
    PDF Downloaded278    
    Comments [Add]    

Recommend this journal