Saudi Journal of Gastroenterology
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Year : 2011  |  Volume : 17  |  Issue : 5  |  Page : 348-352

Concurrent autoimmune hepatitis and grave's disease in Hepatitis C during pegylated Interferon α-2a and ribavirin therapy

1 Department of Internal Medicine, University of Connecticut Medical Center, Farmington, USA
2 Division of Gastroenterology, Hartford Hospital, Hartford, CT, USA

Correspondence Address:
Jonathan L Israel
Division of Gastroenterology, Hartford Hospital, 85 Seymour Street, Suite 1000, CT-06106
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-3767.84494

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Classical interferon-α has been shown to be associated with the development of a variety of autoimmune disorders. A 34-year-old white woman with chronic hepatitis C virus infection who was treated with pegylated interferon α-2a and ribavirin, developed Grave's disease and autoimmune hepatitis (AIH) at 32 and 44 weeks, respectively, following initiation of the therapy. The diagnosis of AIH was made based on the new development of anti-smooth muscle antibodies, anti-mitochondrial antibodies, and liver biopsy findings. It was confirmed by positive response to steroid challenge and was assessed according to the international AIH scoring system. Based on the previous case reports, we review the existing literature. Clinicians should be aware of the possibility of multiple autoimmune disorders during interferon-based therapy for chronic hepatitis.

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