Saudi Journal of Gastroenterology
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Year : 2014  |  Volume : 20  |  Issue : 4  |  Page : 212-218

Epidemiology and pattern of antibiotic resistance in Helicobacter pylori: Scenario from Saudi Arabia


1 Department of Clinical Research, Cell and Molecular Biology Unit, Medical Research Centre, Jazan, Kingdom of Saudi Arabia
2 Department of Microbiology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia
3 Department of Genetics and Molecular Biology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia

Correspondence Address:
Dr. Ayesha Alvi
Department of Genetics and Molecular Biology, Faculty of Applied Medical Sciences, Jazan University, Jazan
Kingdom of Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.136935

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Helicobacter pylori is recognized as a major cause of gastritis, peptic ulcer, gastric cancer, and mucosa-associated lymphoma. Infection with this gram-negative microaerophile has been treated using combination of antibiotics and proton pump inhibitors for different gastrointestinal diseases. The most commonly used treatment is triple therapy which consists of administration of a proton pump inhibitor, clarithromycin, and amoxicillin. Many factors contribute to treatment failure, but one of the main reasons is development of bacterial antibiotic resistance. The percent prevalence of antibiotic resistance varies among different countries; it appears to be partly determined by the geographic factors and its ability to undergo frequent homologous recombination. The aim of this paper is to review the prevalence of H. pylori infection, association of clinical outcomes with H. pylori genotypes, and current status of antibiotic resistance in H. pylori in Saudi Arabia. It also discusses the different alternative approaches for the treatment of H. pylori using antibiotics. In addition, association of antibiotic resistance with H. pylori virulent genotypes in Saudi population and its underlying resistance mechanism will also be discussed.


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