Saudi Journal of Gastroenterology
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Year : 2015  |  Volume : 21  |  Issue : 1  |  Page : 47-50

Prognostic significance of serum galectin-3 levels in patients with hepatocellular cancer and chronic viral hepatitis

1 Bozyaka Training and Research Hospital, Izmir, Turkey
2 Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey
3 Karsiyaka Government Hospital, Izmir, Turkey
4 Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey

Correspondence Address:
Mehmet Ulu
Izmir Katip Celebi University, Ataturk Training and Research Hospital, Medical Oncology Clinic, 35360-Izmir
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-3767.151228

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Background/Aim: Galectins affect diverse physiological and pathophysiological processes such as development, inflammation, and tumor growth. We aimed to compare serum galectin-3 levels in three patient groups with chronic hepatitis B and C virus (HBV, HCV), cirrhosis secondary to HBV or HCV, and hepatocellular carcinoma (HCC) secondary to HBV or HCV and evaluate the role of galectin-3 during HCC progression. Patients and Methods: Nineteen patients with hepatocellular cancer, 22 patients with cirrhosis, and 24 patients with chronic hepatitis B and C were included in this study. Serum galectin-3 levels in different liver diseases were assessed by enzyme-linked immunosorbent assay. Results: The mean galectin-3 levels were 4.61 ng/mL (±2.32) in HCC patients, 5.68 ng/mL (±2,2) in cirrhotic patients, 1.98 ng/mL (±1.50) in chronic viral hepatitis group. There were no statistical differences between HCC and cirrhotic patients (P = 0.5), but lower in chronic hepatitis group statistically compared with cirrhosis and HCC (P < 0.001, P = 0.002, respectively). In case of cirrhotic patients, galectin-3 levels were significantly higher in patients with cirrhosis secondary to HCV compared with HBV (P = 0.03). When we evaluated galectin-3 levels in HCC patients, it was found to be 3.92 ng/mL in HCC secondary to hepatitis B and 5.37 ng/mL in HCC secondary to hepatitis C. Conclusion: Serum galectin-3 levels in patients with chronic HBV or HCV may guide us about progression to cirrhosis or HCC and prognosis of the disease. Especially, galectin-3 levels may be more pronounced in case of HCV.

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