Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2016  |  Volume : 22  |  Issue : 3  |  Page : 215-219

Hepatitis b virus expression and replication in ovum and the influencing factors


1 Department of Infectious Disease and Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
2 Department of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, China
3 Department of Reproductive Center, Shaanxi Maternal and Child Care Hospital, Xi'an, China

Correspondence Address:
Shumei Lin
Department of Infectious Disease and Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an - 710061
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-3767.182456

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Background/Aim: The aim of this study was to investigate the factors that influence hepatitis B virus (HBV) expression and replication in the ovum.Materials and Methods: Immunohistochemistry and in situ hybridization techniques were used to assay the distributions of HBcAg, HBV DNA, and HBV mRNA in ovarian tissues and the ovum in 50 patients with chronic HBV infection. HBeAg and HBV DNA in the serum were also detected. Comparisons of categorical data were performed using McNemar test. Results: The positive rates of HBcAg, HBV DNA, and HBV mRNA in ovum and ovarian tissues of high replication group were significantly higher than low replication group (χ2 = 15.04, P< 0.05; χ2 = 12.96, P<0.05; χ2 = 19.36, P< 0.05; respectively). High positive rates of HBcAg, HBV DNA, and HBV mRNA in ovum and ovarian tissues were found in women with HBeAg-positive than HBeAg-negative (χ2 = 113.14,P< 0.05; χ2 = 11.13, P< 0.05; χ2 = 17.39, P< 0.05; respectively). Conclusion: HBV can infect and replicate in the ovary and ovum. Maternal HBeAg status and HBV DNA levels are important influencing factors.


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