Saudi Journal of Gastroenterology
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SYSTEMATIC REVIEW AND META-ANALYSIS
Year : 2018  |  Volume : 24  |  Issue : 1  |  Page : 12-17

Sarcopenia and risk of nonalcoholic fatty liver disease: A meta-analysis


1 Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York, USA
2 Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
3 Department of Internal Medicine, University of Hawaii, Honolulu, USA
4 Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA; Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Correspondence Address:
Dr. Karn Wijarnpreecha
Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjg.SJG_237_17

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Background/Aim: The association between sarcopenia and nonalcoholic fatty liver disease (NAFLD) has been suggested by recent epidemiological studies, although the results have been inconsistent. This meta-analysis was conducted to summarize all available data and estimate the risk of NAFLD among patients with sarcopenia. Materials and Methods: A comprehensive literature review was conducted using MEDLINE and EMBASE databases through November 2016 to identify all studies that compared the risk of NAFLD among patients with sarcopenia versus those without sarcopenia. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: Five cross-sectional studies with 27,804 participants met the eligibility criteria and were included in the meta-analysis. The risk of NAFLD in patients with sarcopenia was significantly higher than those without sarcopenia with the pooled odds ratio of 1.54 (95% confidence interval, 1.05-2.26). The statistical heterogeneity was high with an I2of 83%. Conclusions: A significantly increased risk of NAFLD among patients with sarcopenia was observed in this study.


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