|Year : 2021 | Volume
| Issue : 2 | Page : 91-96
|Awareness and cognition of illness in Saudi Arabian patients with Crohn's disease
Mahmoud Mosli1, Asala Saeedi2, Majed Alnefaie2, Noor Bawahab2, Lujain Abdo2, Seigha Shobai2, Majid Alsahafi1, Omar Saadah3
1 Department of Medicine, King Abdulaziz University; Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
2 Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
3 Department of Pediatrics, Faculty of Medicine, King Abdulaziz University; Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
Click here for correspondence address and email
|Date of Submission||30-Jun-2020|
|Date of Acceptance||10-Sep-2020|
|Date of Web Publication||12-Mar-2021|
| Abstract|| |
Background: Crohn's disease (CD) is a progressive illness associated with high morbidity owing to the complications associated with the condition. Patients' awareness and cognition of such complications may carry significant psychological impact. The aim of this study is to assess the illness cognition of Saudi patients diagnosed with CD and to identify clinical associations.
Methods: Adult patients with CD were asked to complete an illness cognition questionnaire (ICQ) between January and December of 2019. Additional data was extracted from the medical records. The ICQ composed of three domains: Helplessness (6 items), acceptance (6 items), and perceived benefits (6 items). Descriptive statistics were used to summarize patient characteristics and a linear regression analysis was used to identify associations with the ICQ score.
Results: A total of 88 patients were included, of which 55.8% were females, 18% were smokers, and 11.5% had undergone CD-related surgery. The mean age was 26.9 ± 7.7 years and the mean duration of disease was 54.7 ± 60.5 months. The mean score was 17.4 ± 3.6 for the helplessness domain, 13.4 ± 3.6 for the acceptance domain, and 13.5 ± 3.5 for the perceived benefits domain. We found associations between abdominal pain and acceptance (P = 0.048), extra intestinal manifestations and perceived benefit (P = 0.001), and treatment with mesalamine and helplessness (P = 0.03). In a linear regression analysis, albumin level was the only factor associated with helplessness (coef = 0.18, P = 0.048).
Conclusions: A considerable proportion of Saudi patients diagnosed with CD generally reported a negative perception of their disease. Albumin level was associated with helplessness.
Keywords: Acceptance, Crohn's disease, helplessness, illness cognition, Saudi Arabia
|How to cite this article:|
Mosli M, Saeedi A, Alnefaie M, Bawahab N, Abdo L, Shobai S, Alsahafi M, Saadah O. Awareness and cognition of illness in Saudi Arabian patients with Crohn's disease. Saudi J Gastroenterol 2021;27:91-6
|How to cite this URL:|
Mosli M, Saeedi A, Alnefaie M, Bawahab N, Abdo L, Shobai S, Alsahafi M, Saadah O. Awareness and cognition of illness in Saudi Arabian patients with Crohn's disease. Saudi J Gastroenterol [serial online] 2021 [cited 2021 Jun 22];27:91-6. Available from: https://www.saudijgastro.com/text.asp?2021/27/2/91/311127
| Introduction|| |
Crohn's disease (CD) is increasing in prevalence worldwide. While the etiology is believed to be complex, the most widely accepted hypothesis is that CD is an immune-mediated condition that commonly occurs in genetically susceptible individuals where disease onset is triggered by environmental factors. Moreover, patients affected by this disease may experience a wide range of symptoms such as diarrhea, abdominal pain, fever, and weight loss. Patients' awareness of the chronic recurrent course and uncertain prognosis of these conditions, particularly the risk of complications, including the need for surgery, stoma formation, the development of cancer, associated hospitalizations, frequent physician visits, and the side effects of treatment or surgery, can lead to a wide range of psychological and interpersonal issues in patients. Patients' cognition about the disease and its treatments are important mediators as they may explain the occurrence of differences in the individuals' adjustment to chronic diseases.
In 2001, Evers et al. defined acceptance as a cognitive response that reduces the aversive sense of long-term stressors, such as that associated with chronic diseases. Patients who accept their disease and become aware of their ability to control it have lower levels of psychological distress. However, limited research has been conducted to identify the effect of illness perception on disease activity in inflammatory bowel disease (IBD). Illness cognition can be measured using the illness cognition questionnaire (ICQ) tool. The ICQ has been found to be a reliable and valid instrument for measuring illness cognition across several chronic conditions.,, A previously performed study demonstrated an association between bowel symptoms, social function, and emotional health, based on ICQ measurements. As for correlation between patients' disease cognition and objective measures of inflammation, a significant but relatively modest correlation was found between ICQ and the level of C-reactive protein (CRP) during disease exacerbation and the number, as well as the severity, of relapses of IBD per year.
Therefore, the aim of this study was to examine the degree of illness cognition of Saudi patients with CD and to look for possible associations with positive or negative cognitions.
| Methods|| |
Consecutive patients with confirmed CD seen in the adult outpatient gastroenterology clinic at King Abdulaziz University Hospital (KAUH) were recruited between January and December of 2019. All adult patients diagnosed with CD according to typical clinical, radiological, endoscopic, and histological criteria were included. All patients gave written informed consent prior to participation. Data was collected from interviews with patients and the hospitals' electronic medical records. All patients completed the ICQ, which assesses three main cognitive functions attributable to disease: Helplessness (6 items), acceptance (6 items), and perceived benefits (6 items). Each item was scored from 1 to 4 on a Likert scale, with 1 corresponding to “Not at all,” and 4 corresponding to “Completely.” A total ICQ score varies from 18 to 72, where higher scores in the acceptance and perceived benefits domains reflect better cognition and higher scores in the helplessness domain reflect poorer cognition. King Abdulaziz university ethical committee approval was obtained prior to study commencement (Reference#319-18).
The primary study endpoint was patients' illness cognition, as measured by each domain of the ICQ. The main secondary study endpoint was to identify associations with ICQ in each domain.
The data was analyzed using StataCorp, 2011 (Stata Statistical Software: Release 12. College Station, TX: StataCorp LP). Means and standard deviations (SD) were used to summarize continuous variables and frequencies summarized the categorical variables. A Student t-test compared the mean scores of each domain against clinical and demographic variables. A multivariate linear regression analysis identified potential associations with the total scores for each domain of the ICQ. The level of significance was set at P < 0.05.
| Results|| |
A total of 88 patients were surveyed, of which 55.8% were females, 18% were smokers, and 11.5% had previously undergone CD-related surgery. The mean age was 26.9 ± 7.7 years (range, 12–49 years) and the mean duration of disease was 54.7 ± 60.5 months. Perianal disease was reported by 16.1% of the cohort [Table 1].
Fifty-two percent of the CD patients scored higher on the Likert scale (3 and 4) in the questions related to the helplessness domain and 49% had a high score in the questions related to both acceptance and perceived benefit domains. [Table 2] summarizes the response to individual questions related to each domain.
The mean score was 17.4 ± 3.6 for the helplessness domain, 13.4 ± 3.6 for the acceptance domain, 13.5 ± 3.5 for the perceived benefits domain, and 44.3 ± 6.6 for the total score.
Hypothesis testing of the mean scores of each of the illness cognition domains, comparing helplessness, acceptance, and perceived benefits against a number of different variables, showed that patients reporting abdominal pain demonstrated higher mean scores in the acceptance domain (P = 0.048), patients with extra intestinal manifestations demonstrated lower scores in the perceived benefit domain (P = 0.001), patients treated with mesalamine had lower scores in the helplessness domain (P = 0.03), and a trend toward better acceptance was found in relation to treatment with biological therapy (P = 0.05) [Table 3].
|Table 3: Hypothesis testing of the mean scores for various illness cognition domains and clinical and demographic characteristics|
Click here to view
Associations with different domains in the ICQ score
In a multivariate regression analysis, in the helplessness domain, albumin level was the only significant association with the ICQ score (coef = 0.18, P = 0.048). A trend toward significance was observed for duration of the disease in months (coef = −0.01, P = 0.11) and for smoking (coef = −2.14, P = 0.10) [Table 4]. In the acceptance domain, no associations were identified; however, a trend was found for duration of illness (coef = −0.012, P = 0.15), fatigue (coef = 1.51, P = 0.16), abdominal pain (coef = −1.78, P = 0.09), use of corticosteroids (coef = −1.69, P = 0.18), biological therapy (coef = −1.72, P = 0.08), and surgery (coef = −1.99, P = 0.14). No associations with the perceived benefits domain score were observed, but a trend for duration of illness (coef = −0.015, P = 0.09) and extra-intestinal manifestations (coef = 2.78, P = 0.09) was noted.
|Table 4: Multivariate linear regression analysis for associations with various cognitive domains|
Click here to view
| Discussion|| |
CD is one of the most debilitating forms of chronic inflammatory bowel diseases. It is progressive in nature if not promptly managed, and may result in significant bowel damage, including strictures and fistulae formation, and is associated with an increased probability of requiring surgical bowel resection. This may explain why CD patients are prone to various types of psychological morbidity, including anxiety and depression., Illness cognition is an emerging concept in the psychological literature that measures patient perception, thoughts, and understanding of disease, whether negative or positive. It has been shown to be important in mediating between illness and psychological adjustments and coping with illness. In patients with IBD, the perception of IBD and its natural history has been found to be the most important predictor of adjustment to IBD. The prevalence of psychological morbidity has been correlated with negative illness cognitions and perception, and the positive cognitions have been associated with better disease outcomes.
The cognitive perception of IBD varies between individuals. Some patients may develop a negative perception of its manifestations, such as a feeling of helplessness, which may lead to lack of adherence to the treatment strategy and failure of medical care. Others may cope with their illnesses with more acceptance of their status, culminating in adaptation and self-adjustment. Another category of individuals may have a more positive attitude toward achieving perceived benefits from their illnesses. The helplessness domain represents negative components of illness cognition, while the acceptance and perceived benefits domain represent positive components.
In our study, higher scores in the Likert scale were found in 53% of patients for the helplessness domain, 49% of patients for each of the acceptance and perceived benefits domains. The only association we found between helplessness scores and demographic or clinical variables was with treatment with mesalamine (P = 0.03), where patients treated with mesalamine had lower scores in helplessness domain; this might be reflective of how 5ASA does not provide any additional therapeutic benefit for CD. The mean score in the helplessness domain of our study was 17.4 ± 3.6, which is higher than that reported by Gurkova and Soosova for 51 European patients with CD and which had a helplessness mean score of 11.67 ± 3.34, and higher than Han et al. which reported a mean helplessness score of 13.70 ± 4.24 in Chinese women diagnosed with breast cancer.
Along the same lines, a mean acceptance score in our study of 13.4 ± 3.6 was lower than the mean score of 17.10 ± 3.15 reported for CD patients and the mean score of 16.86 ± 4.30 reported for patients with breast cancer. In addition, we found a lower mean score in perceived benefits (13.5 ± 3.5) compared to the mean score reported in a study of CD patients (16.24 ± 3.37) and a study on women with breast cancer (17.93 ± 3.86)., Our cohort of patients with CD showed a higher mean of negative cognitions and a lower mean of positive cognitions compared to European patients with CD or Chinese women with breast cancer., These findings may be explained by cultural factors, or may reflect the poor prognosis of this specific cohort of patients or the social or ethnic group that they may represent.
It is not yet fully clear which clinical and demographic characteristics are associated with illness cognition in patients with IBD. A study by Verhoof et al. of children with chronic illnesses found that a stable course of illness correlates with more acceptance and less helplessness, the use of medications correlates with more helplessness and less acceptance, tiredness is associated with more helplessness and benefits and less acceptance, having problems with sitting is associated with more helplessness and less acceptance, and patients with perceptible disability reported greater degrees of helplessness. Palgi et al. have found higher acceptance in older patients with gastric cancer than younger patients. In addition, disease duration was associated with higher acceptance in breast cancer women. Our study showed an association between treatment with mesalamine and higher helplessness scores, an association between abdominal pain and higher acceptance scores, and an association between extra-intestinal manifestations and lower perceived benefits scores. We also found that albumin level was the only factor significantly associated with helplessness cognition.
The above results may indicate the lack of patients' adjustment to CD but could also reflect some misconceptions by patients about IBD. Therefore, it is important to identify patients at risk of low degrees of illness cognition early, and to activate a multi-disciplinary approach to help them achieve positive cognitions and minimize negative cognitions through patient education, counseling, engagement, and monitoring. Early referral to a psychologist for counseling and cognitive behavioral therapy may be of value in this respect. The study is limited by its cross-sectional design; a prospective design could detect dynamic changes of cognitions. In addition, the lack of a comparative group of illnesses, which may give greater insight into, and a point of comparison with, the level of disease cognition in patients with CD, is acknowledged.
| Conclusion|| |
A considerable proportion of Saudi patients diagnosed with CD report a negative perception of their disease. Albumin level was found to be associated with helplessness. Patient education and counseling may help improve patients' positive cognition of the disease.
We would like to thank Dr. Trevor Rawbone, Cardiff, UK for kindly reviewing and editing the manuscript.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Ha F, Khalil H. Crohn's disease: A clinical update. Therap Adv Gastroenterol 2015;8:352-9.
Boyapati R, Satsangi J, Ho GT. Pathogenesis of Crohn's disease. F1000Prime Rep 2015;7:44.
Gurkova E, Soosova MS. Illness cognitions and health-related quality of life of patients with inflammatory bowel disease. Gastroenterol Nurs 2018;41:29-37.
Evers AW, Kraaimaat FW, van Lankveld W, Jongen PJ, Jacobs JW, Bijlsma JW. Beyond unfavorable thinking: The illness cognition questionnaire for chronic diseases. J Consult Clin Psychol 2001;69:1026-36.
Evers AW, Lu Y, Duller P, van der Valk PG, Kraaimaat FW, van de Kerkhof PC. Common burden of chronic skin diseases? Contributors to psychological distress in adults with psoriasis and atopic dermatitis. Br J Dermatol 2005;152:1275-81.
Lauwerier E, Crombez G, Van Damme S, Goubert L, Vogelaers D, Evers AW. The construct validity of the illness cognition questionnaire: The robustness of the three-factor structure across patients with chronic pain and chronic fatigue. Int J Behav Med 2010;17:90-6.
Verhoof EJ, Maurice-Stam H, Heymans HS, Evers AW, Grootenhuis MA. Psychosocial well-being in young adults with chronic illness since childhood: The role of illness cognitions. Child Adolesc Psychiatry Ment Health 2014;8:12.
Koelewijn CL, Schwartz MP, Samsom M, Oldenburg B. C-reactive protein levels during a relapse of Crohn's disease are associated with the clinical course of the disease. World J Gastroenterol 2008;14:85-9.
Aniwan S, Park SH, Loftus EV Jr. Epidemiology, natural history, and risk stratification of Crohn's disease. Gastroenterol Clin North Am 2017;46:463-80.
Brooks AJ, Norman P, Peach EJ, Ryder A, Scott AJ, Narula P, et al
. Prospective study of psychological morbidity and illness perceptions in young people with inflammatory bowel disease. J Crohns Colitis 2019;13:1003-11.
Neuendorf R, Harding A, Stello N, Hanes D, Wahbeh H. Depression and anxiety in patients with inflammatory bowel disease: A systematic review. J Psychosom Res 2016;87:70-80.
Searle A, Norman P, Thompson R, Vedhara K. A prospective examination of illness beliefs and coping in patients with type 2 diabetes. Br J Health Psychol 2007;12:621-38.
Sint Nicolaas SM, Schepers SA, van den Bergh EMM, Evers AWM, Hoogerbrugge PM, Grootenhuis MA, et al
. Illness cognitions and family adjustment: Psychometric properties of the illness cognition questionnaire for parents of a child with cancer. Support Care Cancer 2016;24:529-37.
Dorrian A, Dempster M, Adair P. Adjustment to inflammatory bowel disease: The relative influence of illness perceptions and coping. Inflamm Bowel Dis 2009;15:47-55.
Berding A, Witte C, Gottschald M, Kaltz B, Weiland R, Gerlich C, et al
. Beneficial effects of education on emotional distress, self-management, and coping in patients with inflammatory bowel disease: A prospective randomized controlled study. Inflamm Intest Dis 2017;1:182-90.
Han J, Liu JE, Qiu H, Nie ZH, Su YL. Illness cognitions and the associated socio-demographic and clinical factors in Chinese women with breast cancer. Eur J Oncol Nurs 2018;32:33-9.
Palgi Y, Ben-Ezra M, Hamama-Raz Y, Shacham Shmueli E, Shrira A. The effect of age on illness cognition, subjective well-being and psychological distress among gastric cancer patients. Stress Health 2014;30:280-6.
Wahed M, Corser M, Goodhand JR, Rampton DS. Does psychological counseling alter the natural history of inflammatory bowel disease? Inflamm Bowel Dis 2010;16:664-9.
Dr. Mahmoud Mosli
Department of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah
Source of Support: None, Conflict of Interest: None
[Table 1], [Table 2], [Table 3], [Table 4]
| Article Access Statistics|
| Viewed||621 |
| Printed||8 |
| Emailed||0 |
| PDF Downloaded||46 |
| Comments ||[Add] |