Palliative endoscopic retrograde biliary drainage for malignant biliary obstruction in Korea: A nationwide assessment
Dong Kee Jang1, Jungmee Kim2, Seung Bae Yoon3, Won Jae Yoon4, Jung-Wook Kim5, Tae Hee Lee6, Jae-Young Jang5, Chang Nyol Paik7, Jun Kyu Lee1
1 Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Republic of Korea
2 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
3 Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
4 Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea
5 Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea
6 Institute for Digestive Research, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea
7 Department of Internal Medicine, Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Dr. Jun Kyu Lee
Department of Internal Medicine, Dongguk University College of Medicine, Dongguk University Ilsan Hospital, 27 Dongguk-ro, Ilsandong-gu, Goyang, 10326
Republic of Korea
Source of Support: None, Conflict of Interest: None
Background: Malignant biliary obstruction (MBO) is usually caused by biliary tract cancer or pancreatic cancer. This study was performed to summarize the current situation regarding palliative endoscopic retrograde biliary drainage (ERBD) for MBO in Korea and to determine its clinical significance by analyzing representative nationwide data.
Methods: Patients that underwent palliative ERBD for MBO between 2012 and 2015 were identified using the Health Insurance Review and Assessment database, which covers the entire Korean population. We assessed clinical characteristics and complications and compared the clinical impacts of initial metal and plastic stenting in these patients.
Results: A total of 9,728 subjects (mean age, 65 ± 11.4 years; male, 61.4%) were identified and analyzed. The most common diagnosis was malignant neoplasm of liver and intrahepatic bile ducts (32.1%) and this was followed by extrahepatic or Ampulla of Vater cancer and pancreatic cancer. Initial plastic stent(s) placement was performed in 52.9% of the study subjects, and metal stent(s) placement was performed in 23.3%. The number of sessions of endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic biliary drainage (PTBD) was significantly higher in patients that underwent initial plastic stenting than in patients that underwent metal stenting (2.2 ± 1.7 vs 1.8 ± 1.4, P < 0.0001), but rates of post-ERCP pancreatitis, hospital days, and time to second ERCP or PTBD were not significantly different.
Conclusion: This nationwide assessment study suggests that initial metal stenting is associated with fewer sessions of total ERCP or PTBD following the initial procedure, despite the preference for initial plastic stenting in Korea.