Saudi Journal of Gastroenterology
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Is the nuclear factor kappa-b (NF-κB) pathway and inflammatory status associated with colorectal cancer?

1 Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara, Turkey
2 Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Health Sciences Gülhane, Ankara, Turkey
3 Department of Medical Oncology, University of Health Sciences, Ankara, Turkey

Correspondence Address:
Büşra Atabilen,
Emek Neighborhood Bişkek Street, 6th Street (Former 81st Street), Gazi University Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sjg.sjg_44_21

PMID: 34380870

Background: Although genetic predisposition has a role in the etiology of colorectal cancer, there are many other factors that affect its development. In this study, it was aimed to evaluate the NF-κB pathway, inflammatory status and dietary antioxidant capacity in individuals with colorectal cancer. Methods: The study was carried out with 40 male subjects diagnosed with colorectal cancer aged between 39-65, years and a control group of the same number of healthy men. Subjects in the case and control groups were subdivided according to body mass index (BMI), as normal (BMI 20-24.9 kg/m2) or overweight/obese (BMI ≥25 kg/m2). Results: At the end of the study, NF-κB and interleukin-22 levels were higher in the case group, but no significant difference was found between the groups. Interleukin-23 and 8-Hydroxy-2-deoxyguanosine levels in the case group classified as overweight/obese according to BMI were significantly higher than in the control group (P = 0.001 and P < 0.001, respectively). Considering diet antioxidant capacity, it was higher in individuals in the control group than in the case group. However, there was no significant difference between the groups. Conclusion: Inflammatory status and reduced dietary antioxidant capacity are risk factors in the development of colorectal cancer.

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