Saudi Journal of Gastroenterology

ARTICLES
Year
: 1995  |  Volume : 1  |  Issue : 2  |  Page : 93--96

Reduction in the prevalence of antibody to hepatitis A virus among young Saudi adults: Implications for hepatitis A vaccine


M Arif1, FZ Al-Faleh2, AR Al-Frayh3, S Ramia1 
1 Department of Pathology, College of Medicine, P.O. Box 2925, Riyadh 11461, Saudi Arabia
2 Department of Internal Medicine, College of Medicine, P.O. Box 2925, Riyadh 11461, Saudi Arabia
3 Department of Pediatrics, College of Medicine, P.O. Box 2925, Riyadh 11461, Saudi Arabia

Correspondence Address:
S Ramia
Department of Pathology (32), College of Medicine, P.O. Box 2925, Riyadh 11461
Saudi Arabia

Viral etiology was investigated in 133 Saudi patients with acute hepatitis seen in King Khalid University Hospital, Riyadh. between July 1993-May 1994. Out of the 133 patients, 51 (38.3%) were diagnosed as having acute hepatitis due to hepatitis A virus (HAV). Hepatitis C virus (HCV) was the second most common etiological agent (20.3%). There were 35 patients with acute hepatitis (26.3%) in whom no viral marker for HAV, HBV, HCV, CMV or Epstein-Barr virus (EBV) was detected. Among the 51 patients with acute hepatitis due to HAV, the major­ity (88.2%) were children (1-12 years) and only 6 (11.8%) were adults (15-24 years). This is in contrast to patients with HCV or HBV infection where the majority were adults: 74.1% and 82.3% respectively. The diagnosis of acute hepatitis due to HAV in Saudi adults, an observa­tion not seen earlier, indicated a change in the epidemiological pattern of HAV infection in the Saudi population. This change was confirmed by the significant reduction in the prevalence of anti-HAV in 630 Saudi subjects (1-30 years old) (50.2%) investigated in 1994 compared to that of 587 subjects of the same age group investigated in 1986 (76.5%) (P < 0.005). In the light of these results, a nation-wide survey is recommended to confirm this pattern in other areas. It is important that high-risk Saudi groups be identified and evaluated for their anti-HAV status as these groups are candidates for HAV vaccination.


How to cite this article:
Arif M, Al-Faleh F Z, Al-Frayh A R, Ramia S. Reduction in the prevalence of antibody to hepatitis A virus among young Saudi adults: Implications for hepatitis A vaccine.Saudi J Gastroenterol 1995;1:93-96


How to cite this URL:
Arif M, Al-Faleh F Z, Al-Frayh A R, Ramia S. Reduction in the prevalence of antibody to hepatitis A virus among young Saudi adults: Implications for hepatitis A vaccine. Saudi J Gastroenterol [serial online] 1995 [cited 2021 Dec 1 ];1:93-96
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=1995;volume=1;issue=2;spage=93;epage=96;aulast=Arif;type=0