Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 16  |  Issue : 2  |  Page : 79--83

Serum paraoxonase 1 activity status in patients with liver disorders


Vivekananda Kedage, Manjunatha S Muttigi, Mahesh S Shetty, Renuka Suvarna, Soumya S Rao, Chitralekha Joshi, Mungli Prakash 
 Department of Biochemistry, Kasturba Medical College, Manipal, India

Correspondence Address:
Mungli Prakash
Department of Biochemistry, Kasturba Medical College, Manipal
India

Background/Aim: Paraoxonase 1 (PON1) is an esterase, exclusively synthesized by liver. The present study has two objectives: to determine the PON1 activity status in various disorders associated with hepatocellular damage and to correlate the changes of PON1 activity with the standard liver function and fasting lipid profile tests in these disorders. Patients and Methods: The study groups consisted of 95 patients with liver diseases including acute viral hepatitis (14), cirrhosis with portal hypertension (33), leptospirosis (14), sepsis and multi organ failure (15), left ventricular failure (9), and falciparum malaria (10); and 53 healthy controls. Serum PON1 activity was measured manually using spectrophotometer. Liver function test parameters and fasting lipid profile were performed in clinical chemistry auto analyzer (Hitachi 912). Results: The serum PON1 activity in patients with acute viral hepatitis and sepsis decreased significantly ( P <0.001) and moderately in falciparum malaria ( P <0.05). However, in patients with cirrhosis, leptospirosis and left ventricular patients, its activity did not change significantly. On applying Pearson correlation, serum PON1 activity correlated positively with high-density lipoprotein-cholesterol (HDL-C) in patients with sepsis (r=0.633, P <0.05), left ventricular failure patients (r=0.814, P <0.05) and negatively with acute viral hepatitis patients (r=- 0.528, P <0.05). Conclusion: PON1 activity has decreased significantly in acute viral hepatitis, sepsis with multi organ failure and falciparum malaria patients. Determination of PON1 activity may serve as a useful additional test in assessing these conditions.


How to cite this article:
Kedage V, Muttigi MS, Shetty MS, Suvarna R, Rao SS, Joshi C, Prakash M. Serum paraoxonase 1 activity status in patients with liver disorders.Saudi J Gastroenterol 2010;16:79-83


How to cite this URL:
Kedage V, Muttigi MS, Shetty MS, Suvarna R, Rao SS, Joshi C, Prakash M. Serum paraoxonase 1 activity status in patients with liver disorders. Saudi J Gastroenterol [serial online] 2010 [cited 2021 Jun 23 ];16:79-83
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2010;volume=16;issue=2;spage=79;epage=83;aulast=Kedage;type=0