Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 17  |  Issue : 2  |  Page : 114--118

Effect of interferon treatment on hearing of patients with chronic Hepatitis C


Abdulrahman Hagr1, Dima Jamjoom1, Faisal M Sanai2, Waleed Al Hamoudi3, Ayman A Abdo3, Ahmed Al-Arfaj1 
1 Department of ENT, College of Medicine, King Saud University, Riyadh, Saudi Arabia
2 Department of Medicine, Division of Gastroenterology & Hepatology, Riyadh Military Hospital, Riyadh, Saudi Arabia
3 Gastroenterology Division, Department of Medicine, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Ahmed Al-Arfaj
Department of Otolaryngology, College of Medicine, King Saud University, P .O. Box 245, Riyadh 11411
Saudi Arabia

Background/Aim: Some reports in the literature have linked interferon therapy for the treatment of hepatitis C (HCV) with hearing loss. The aim of this study has been to examine the effects of interferon therapy on hearing of patients treated for HCV. Patients and Methods: Patients were recruited according to preset inclusion criteria from two centers. All patients received standard dose pegylated interferon (PEG-IFN a-2b or a-2a) plus ribavirin (RBV). All patients had pure-tone audiometry (PTA), tympanogram and distortion-product otoacoustic emission (DPOAE) before treatment, three months after initiation of treatment, and three months after completion of treatment. Results: Twenty one patients were prospectively recruited. The mean age was 45.7 years. The male to female ratio was 1.1:1. The mean PTA was 15.9 ± 5.3 before treatment, 17.4 ± 6.1 during treatment and 16.5 ± 5.1 after treatment. The differences between pre and mid, pre and post, as well as mid and post were not significantly different (P>0.05) in all audiological assessments. Conclusions: Our results indicate that PEG-IFN\RBV therapy does not have any impact on the hearing thresholds of patients with HCV.


How to cite this article:
Hagr A, Jamjoom D, Sanai FM, Al Hamoudi W, Abdo AA, Al-Arfaj A. Effect of interferon treatment on hearing of patients with chronic Hepatitis C.Saudi J Gastroenterol 2011;17:114-118


How to cite this URL:
Hagr A, Jamjoom D, Sanai FM, Al Hamoudi W, Abdo AA, Al-Arfaj A. Effect of interferon treatment on hearing of patients with chronic Hepatitis C. Saudi J Gastroenterol [serial online] 2011 [cited 2023 Jan 31 ];17:114-118
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2011;volume=17;issue=2;spage=114;epage=118;aulast=Hagr;type=0