Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 18  |  Issue : 3  |  Page : 188--194

The protective role of Aegle marmelos on aspirin-induced gastro-duodenal ulceration in albino rat model: A possible involvement of antioxidants


Shyamal K Das1, Chandan Roy2 
1 Department of Physiology, Krishnath College, University of Kalyani, Berhampore, Murshidabad, India
2 Department of Physiology, Katwa College, University of Burdwan, P.O. Katwa, District. Burdwan, West Bengal, India

Correspondence Address:
Chandan Roy
Department of Physiology, Katwa College, P.O. Katwa, District. Burdwan - 713 130, West Bengal
India

Background/Aim: Gastro duodenal ulcer is a common disorder of the gastrointestinal tract. Several Indian medicinal plants have been traditionally and extensively used to prevent different diseases. In the present research studies, Bael fruit (Aegle marmelos (AM), family: Rutaceae) which are also called as Bilva in ancient Sanskrit was used as a herbal drug and its antioxidative role in aspirin- induced gastroduodenal ulceration in albino rat was evaluated using essential biochemical parameters. Patients and Methods: Mucosal thickness (MT), ulcer index (UI), different biochemical parameters, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and lipid peroxidation (LPO) were measured in all the groups, to study the possible involvement of antioxidants with gastroduodenal protection. Results: A significant decrease in MT, SOD and CAT activities and GSH level and a significant increase in UI, AST, ALT, and ALP activities and LPO level were observed in aspirin treated stomach and duodenum of albino rats. Conclusions: Pretreatment with AM fruit pulp extract for 14 consecutive days showed the reverse effects of aspirin suggesting gastro-duodenal protective and anti- ulcerogenic properties of AM through its antioxidant mechanism.


How to cite this article:
Das SK, Roy C. The protective role of Aegle marmelos on aspirin-induced gastro-duodenal ulceration in albino rat model: A possible involvement of antioxidants.Saudi J Gastroenterol 2012;18:188-194


How to cite this URL:
Das SK, Roy C. The protective role of Aegle marmelos on aspirin-induced gastro-duodenal ulceration in albino rat model: A possible involvement of antioxidants. Saudi J Gastroenterol [serial online] 2012 [cited 2021 Apr 14 ];18:188-194
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2012;volume=18;issue=3;spage=188;epage=194;aulast=Das;type=0